The role of c-reactive protein in cardiovascular disease risk

被引:20
作者
Albert M.A. [1 ]
机构
[1] Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115
关键词
Hormone Replacement Therapy; Pravastatin; Arterioscler Thromb Vasc Biol; Pravastatin Sodium; Multiple Risk Factor Interventional Trial;
D O I
10.1007/s11886-000-0081-7
中图分类号
学科分类号
摘要
Over the past few years, a flurry of data in the medical literature has strongly implicated C-reactive protein (CRP) as a marker of inflammation in coronary artery disease (CAD). Recognizing the likely integral role that inflammation plays in the pathogenesis of atherosclerosis, many hospital laboratories have tests to measure CRP concentration in the clinical setting. However, the clinical use of these tests still need definition. To date, of the plasma-based markers investigated, CRP provides the strongest risk prediction for cardiovascular disease in men and women. Questions remain regarding the degree to which CRP can improve risk stratification beyond that of the traditional risk factors of CAD. Copyright © 2000 by Current Science Inc.
引用
收藏
页码:274 / 279
页数:5
相关论文
共 35 条
  • [1] Kuller L.H., Tracy R.P., Shaten J., Meilahn E.N., Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor Intervention Trial, Am J Epidemiology, 144, pp. 537-547, (1996)
  • [2] Ridker P.M., Cushman M., Stampfer M.J., Et al., Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men, N Engl J Med, 336, pp. 973-979, (1997)
  • [3] Koenig W., Sund M., Frohlich M., Et al., C-reactive protein, a sensitive marker of coronary heart disease in initially healthy middle aged men: Results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992, Circulation, 99, pp. 237-242, (1999)
  • [4] Ridker P.M., Buring J.E., Shih J., Et al., Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women, Circulation, 98, pp. 731-733, (1998)
  • [5] Tracy R.P., Lemaitre R.N., Psaty B.M., Et al., Relationship of C-reactive protein to risk of cardiovascular disease in the elderly: Results from the Cardiovascular Health Study and the Rural Health Promotion Project, Arterioscler Thromb Vasc Biol, pp. 1121-1127, (1997)
  • [6] Ridker P.M., Hennekens C.H., Rifai N., Et al., Hormone replacement therapy and increased concentration of C-reactive protein, Circulation, 100, pp. 713-716, (1999)
  • [7] Visser M., Bouter L.M., McQuillan G.M., Et al., Elevated C-reactive protein levels in overweight and obese adults, JAMA, 282, pp. 2131-2135, (1999)
  • [8] Stenvinkel P., Heimburger O., Paultre F., Et al., Strong association between malnutrition, inflammation and atherosclerosis in chronic renal failure, Kidney Int, 55, pp. 1889-1911, (1999)
  • [9] Ridker P.M., Rifai N., Pfeffer M.A., Et al., Long term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators, Circulation, 100, pp. 230-235, (1999)
  • [10] Libby P., Ridker P.M., Novel inflammatory markers of coronary risk theory versus practice, Circulation, 100, pp. 1148-1150, (1999)