Glycotoxins in the diet promote diabetes and diabetic complications

被引：59

作者：

Vlassara H. ^{[1
]}

Striker G. ^{[1
]}

机构：

[1] Division of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, One Gustave Levy Place

来源：

Current Diabetes Reports | 2007年 / 7卷 / 3期

关键词：

Diabetic Complication; Aldose Reductase; Methylglyoxal; Benfotiamine; Dietary AGEs;

D O I：

10.1007/s11892-007-0037-z

中图分类号：

学科分类号：

摘要：

Oxidant stress underlines diabetes and diabetic complications, including cardiovascular, renal, and retinal disease. Advanced glycation and products (AGEs), or glycotoxins, are a significant contributor to oxidant stress in diabetes. The diet is a major, unrecognized source of AGEs. Importantly, reduction of dietary AGEs decreases circulating inflammatory markers in both diabetic patients and prediabetic patients complications in animal models. This beneficial outcome requires only a 50% decrease in dietary AGEs, making this necessary intervention practical and inexpensive. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：235 / 241

页数：6

共 49 条

[1]

The Diabetes Control and Complications Trial Research Group [no authors listed], N Engl J Med, 329, pp. 977-986, (1993)

[2]

Monnier V.M., Bautista O., Kenny D., Et al., Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes, Diabetes, 48, pp. 870-880, (1999)

[3]

Maillard L.C., Action des acides amines sur les sucres: Formation des malaniodines par voie methodique, C R Acad Sci, 154, pp. 66-68, (1912)

[4]

Cai W., Gao Q.D., Zhu L., Et al., Oxidative stress-inducing carbonyl compounds from common foods: Novel mediators of cellular dysfunction, Mol Med, 8, pp. 337-346, (2002)

[5]

Goldberg T., Cai W., Peppa M., Et al., Advanced glycoxidation endproducts in commonly consumed foods, J Am Diet Assoc, 104, pp. 1287-1291, (2004)

[6]

Vlassara H., Cai W., Crandall J., Et al., Inflammatory mediators are induced by dietary glycotoxins: A major risk factor for diabetic angiopathy, Proc Natl Acad Sci U S A, 99, pp. 15596-15601, (2002)

[7]

Frye E.B., Degenhardt T.P., Thorpe S.R., Baynes J.W., Role of the Maillard reaction in aging of tissue proteins. Advanced glycation end product-dependent increase in imidazolium cross-links in human lens proteins, J Biol Chem, 273, pp. 18714-18719, (1998)

[8]

Miyata T., van Ypersele C., Kurokawa K., Baynes J.W., Alterations in nonenzymatic biochemistry in uremia: Origin and significance of "carbonyl stress" in long-term uremic complications, Kidney Int, 55, pp. 389-399, (1999)

[9]

Bucala R., Makita Z., Koschinsky T., Et al., Lipid advanced glycosylation: Pathway for lipid oxidation in vivo, Proc Natl Acad Sci U S A, 90, pp. 6434-6438, (1993)

[10]

Abordo E.A., Minhas H.S., Thornalley P.J., Accumulation of alpha-oxoaldehydes during oxidative stress: A role in cytotoxicity, Biochem Pharmacol, 58, pp. 641-648, (1999)

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