Comorbidity in finnish migraine families

被引：20

作者：

Artto V. ^{[1
]}

Wessman M. ^{[2
,3
]}

Nissilä M. ^{[4
]}

Säkä E. ^{[4
]}

Liukkonen J. ^{[5
]}

Teirmaa H. ^{[6
]}

Harno H. ^{[1
]}

Havanka H. ^{[7
]}

Ilmavirta M. ^{[8
]}

Palotie A. ^{[9
,10
]}

Färkkilä M. ^{[1
]}

Kallela M. ^{[1
]}

机构：

[1] Department of Neurology, Helsinki University Central Hospital, Helsinki

[2] The Finnish Genome Center, Helsinki

[3] Folkhälsan Research Center, Helsinki

[4] Turku Headache Center, Turku

[5] Mikkeli Neurology Center, Mikkeli

[6] Etelä-Pohjanmaa Headache Center, Etelä-Pohjanmaa

[7] Department of Neurology, Länsi-Pohja Central Hospital, Länsi-Pohja

[8] Suomen Terveystalo, Jyväskylä

[9] Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, CA

[10] Department of Clinical Chemistry, University of Helsinki, Helsinki

来源：

The Journal of Headache and Pain | 2006年 / 7卷 / 5期

基金：

芬兰科学院; 美国国家卫生研究院;

关键词：

Allergy; Comorbidity; Family studies; Hypotension; Migraine; Psychiatric disorder;

D O I：

10.1007/s10194-006-0319-x

中图分类号：

学科分类号：

摘要：

The objective of the study was to investigate comorbidity of migraine in Finnish migraine families. One thousand consecutive participants in the Finnish Migraine Gene Project reported their medical illnesses in addition to migraine and headache. Migraine patients (n=678) reported significantly more hypotension (OR 1.43, CI 95% 1.02-2.01), allergy (OR 1.83, CI 95% 1.34-2.51) and psychiatric disorders (OR 4.09, CI 95% 2.11-7.92) compared to their family members without migraine (n=322). Subgroup analyses demonstrated that especially women and the group fulfilling the criteria for both migraine with and without aura were likely to have additional disorders besides their migraine. Interestingly, male migraineurs with aura reported a significant association with stroke and epilepsy. Familial migraine is comorbid with hypotension, allergy and psychiatric disorders. The association between migraine with aura and stroke and epilepsy among men of the studied families warrants further study. Clinical, pathophysiological and genetic implications of these results are discussed. © Springer-Verlag Italia 2006.

引用

页码：324 / 330

页数：6

共 16 条

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