Fish Drug Analysis - Phish-Pharm: A searchable database of pharmacokinetics data in fish

被引：15

作者：

Reimschuessel R. ^{[1
]}

Stewart L. ^{[2
]}

Squibb E. ^{[3
]}

Hirokawa K. ^{[4
]}

Brady T. ^{[4
]}

Brooks D. ^{[5
]}

Shaikh B. ^{[1
]}

Hodsdon C. ^{[6
]}

机构：

[1] Center for Veterinary Medicine, United States Food and Drug Administration, Laurel, MD 20708

[2] Northwestern University, Evanston

[3] University of Maryland, College Park

[4] St George's University, St. George's

[5] Center for Veterinary Medicine, US Food and Drug Administration, Rockville

[6] Independent Computing, Drumore, PA 17518

来源：

The AAPS Journal | / 7卷 / 2期

关键词：

Aquatic; Database; Drug; Fish; Pharmacokinetics; Residues; Web;

D O I：

10.1208/aapsj070230

中图分类号：

学科分类号：

摘要：

Information about drug residues and pharmacokinetic parameters in aquatic species is relatively sparse. In addition, it is difficult to rapidly compare data between studies due to differences in experimental conditions, such as water temperatures and salinity. To facilitate the study of aquatic species drug metabolism, we constructed a Fish Drug/Chemical Analysis Phish-Pharm (FDA-PP) database. This database consists of more than 400 articles that include data from 90 species (64 genera) of fish. Data fields include genus, species, water temperatures, the average animal weight, sample types analyzed, drug (or chemical) name, dosage, route of administration, metabolites identified, method of analysis, protein binding, clearance, volume of distribution in a central compartment (Vc) or volume of distribution at steady-state (Vd), and drug half-lives (t1/2). Additional fields list the citation, authors, title, and Internet links. The document will be periodically updated, and users are invited to submit additional data. Updates will be announced in future issues of The AAPS Journal. This database will be a valuable resource to investigators of drug metabolism in aquatic species as well as government and private organizations involved in the drug approval process for aquatic species. Copyright ©2003. All Rights Reserved.

引用

页数：40

共 38 条

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[2]

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[3]

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[4]

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[5]

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[6]

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[7]

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[8]

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[9]

Minor Use for Minor Species Animal Health Act, (2005)

[10]

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