Mitochondrial defects in cancer

被引：458

作者：

Carew J.S. ^{[1
,2
]}

Huang P. ^{[1
,2
]}

机构：

[1] Department of Molecular Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030

[2] Grad. School of Biomedical Sciences, University of Texas Health Sci. Ctr., Houston, TX 77030

来源：

Molecular Cancer | / 1卷 / 1期

关键词：

Cancer; Free radical; Mitochondria; Mutation; Respiration;

D O I：

10.1186/1476-4598-1-9

中图分类号：

学科分类号：

摘要：

Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progression of cancer. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in various types of cancer, and offer some perspective as to the emergence of mtDNA mutations, their functional consequences in cancer development, and therapeutic implications. © 2002 Carew and Huang; licensee BioMed Central Ltd.

引用

页数：12

共 92 条

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