Chemokines and their role in airway hyper-reactivity

被引：33

作者：

Blease K. ^{[1
]}

Lukacs N.W. ^{[1
]}

Hogaboam C.M. ^{[1
]}

Kunkel S.L. ^{[1
]}

机构：

[1] Department of Pathology, Univ. of Michigan Medical School, Ann Arbor, MI 48109

来源：

Respiratory Research | 2000年 / 1卷 / 1期

关键词：

Asthma; Eosinophils; Fibrosis; T cells;

D O I：

10.1186/rr13

中图分类号：

学科分类号：

摘要：

Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in several pathological processes that are believed to contribute to airway hyperresponsiveness, including recruitment and activation of inflammatory cells, collagen deposition and airway wall remodeling. These proteins are therefore thought to represent important therapeutic targets in the treatment of airway hyper-responsiveness. This review highlights the processes thought to be involved in airway hyper-responsiveness in allergic asthma, and the role of chemokines in these processes. Overall, the application of chemokines to the prevention or treatment of airway hyper-reactivity has tremendous potential.

引用

页码：54 / 61

页数：7

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