Persistence of oxidant and protease burden in the airways after smoking cessation

被引：70

作者：

Louhelainen N. ^{[2
]}

Rytilä P. ^{[1
,2
]}

Haahtela T. ^{[1
]}

Kinnula V.L. ^{[2
]}

Djukanović R. ^{[3
]}

机构：

[1] Department of Medicine, Division of Allergy, University of Helsinki, Helsinki

[2] Department of Medicine, Division of Pulmonary Medicine, University of Helsinki, Helsinki

[3] Division of Infection, Inflammation and Repair, Southampton General Hospital, Southampton

来源：

BMC Pulmonary Medicine | / 9卷 / 1期

关键词：

Smoking Cessation; Sputum Sample; Exhale Breath Condensate; Sputum Specimen; Oxidant Marker;

D O I：

10.1186/1471-2466-9-25

中图分类号：

学科分类号：

摘要：

Background: Oxidative stress is associated with the pathogenesis of cigarette smoke related lung diseases, but longitudinal effects of smoking cessation on oxidant markers in the airways are unknown. Methods: This study included 61 smokers; 21 with chronic bronchitis or COPD, 15 asthmatics and 25 asymptomatic smokers followed up for 3 months after smoking cessation. Fractional exhaled nitric oxide (FeNO), sputum neutrophil counts, sputum 8-isoprostane, nitrotyrosine and matrix metalloproteinase-8 (MMP-8) were investigated at baseline and 1 and 3 months after smoking cessation. Results: After 3 months 15 subjects had succeeded in quitting of smoking and in these subjects symptoms improved significantly. Unexpectedly, however, sputum neutrophils increased (p = 0.046) after smoking cessation in patients with chronic bronchitis/COPD. At baseline, the other markers did not differ between the three groups so these results were combined for further analysis. Sputum 8-isoprostane declined significantly during the follow-up at 3 months (p = 0.035), but levels still remained significantly higher than in non-smokers. The levels of FeNO, nitrotyrosine and MMP-8 did not change significantly during the 3 months after smoking cessation. Conclusion: Whilst symptoms improve after smoking cessation, the oxidant and protease burden in the airways continues for months. © 2009 Louhelainen et al; licensee BioMed Central Ltd.

引用

共 55 条

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