Pathogenesis-related adhesion molecules in Henoch–Schonlein vasculitis

被引：19

作者：

Faysal Gok

Yesim Ugur

Seza Ozen

Attila Dagdeviren

机构：

[1] Gulhane Military Medical Academy,Department of Pediatric Nephrology

[2] School of Medicine,Department of Histology

[3] Hacettepe University Medical Faculty,Embryology

[4] Hacettepe University Medical Faculty,Department of Pediatric Nephrology and Rheumatology Unit

来源：

Rheumatology International | 2008年 / 28卷

关键词：

Henoch–Schonlein; Skin; Selectin; ICAM; VCAM;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The aim of this study was to reveal the distribution of various inflammation and endothelium-related adhesion molecules, namely, P-selectin, E-selectin, ICAM-1, ICAM-2, ICAM-3 and VCAM-1, on the skin samples of patients with Henoch–Schonlein purpura. Skin biopsies obtained from 12 pediatric patients at the acute purpura phase and from 5 patients at the convalescent phase of the disease were included in the study. Endothelial expression of P-selectin (P < 0.05), endothelial and inflammatory cellular expressions of ICAM-2 (P < 0.05, P < 0.01) and inflammatory cellular expression of ICAM-3 (P < 0.05) were significantly more intense when compared to patients in the convalescent phase. Although endothelial E-selectin and VCAM-1 expressions, and endothelial and inflammatory cellular ICAM-1 expressions displayed a decrease in the convalesant phase, this difference was not found to be statistically significant (P > 0.05).

引用

页码：313 / 316

页数：3

共 89 条

[1]

Athreyal BH(1995)Vasculitis in children Ped Clin North Am 42 1239-1261

[2]

Jennette JC(1994)Nomenclature of systemic vasculitides. Proposal of an international consensus conference Arthr Rheum 37 187-192

[3]

Falk RJ(1999)Henoch–Schonlein purpura Rheumatology 80 380-383

[4]

Andrassy K(1999)Henoch–Schonlein purpura nephritis J Am Soc Nephrol 10 2637-2644

[5]

Bacon PA(1999)The American College of Rheumatology 1990 criteria for classification of Henoch–Schönlein purpura Arthritis Rheum 33 1114-1121

[6]

Churg J(2006)EULAR/PRES endorsed consensus criteria* for the classification of childhood vasculitides Ann Rheum Dis 65 7-941

[7]

Gross WL(1999)VCAM-1, ICAM-1 and E-selectin in IgA nephropathy and Henoch–Schonlein syndrome: differences between tissue expression and serum concentration Nephron 81 256-263

[8]

Hagen EC(1996)Circulating adhesion molecules ICAM-1, E-selectin and Von-Willebrand factor in Henoch–Schonlein purpura Arch Dis Child 75 507-511

[9]

Hoffman GS(1998)Dynamic pattern of endothelial cell adhesion molecule expression in muscle and perineural vessels from patients with classic polyarteritis nodosa Arthritis Rheum 41 435-444

[10]

Hunder GG(1997)Circulating soluble selectins in Kawasaki disease Clin Exp Immunol 108 446-450

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