The association of APOE genotype and cognitive decline in interaction with risk factors in a 65-69 year old community sample

被引：49

作者：

Christensen H. ^{[1
]}

Batterham P.J. ^{[1
]}

Mackinnon A.J. ^{[1
,2
]}

Jorm A.F. ^{[2
]}

Mack H.A. ^{[1
]}

Mather K.A. ^{[1
]}

Anstey K.J. ^{[1
]}

Sachdev P.S. ^{[3
,4
]}

Easteal S. ^{[1
]}

机构：

[1] Australian National University, Canberra, ACT

[2] University of Melbourne, Melbourne, VIC

[3] School of Psychiatry, University of New South Wales, Sydney, NSW

[4] Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW

来源：

BMC Geriatrics | / 8卷 / 1期

基金：

英国医学研究理事会;

关键词：

Cognitive Decline; Head Injury; APOE Genotype; Simple Reaction Time; Current Alcohol Consumption;

D O I：

10.1186/1471-2318-8-14

中图分类号：

学科分类号：

摘要：

Background. While the evidence of an association between the apolipoprotein E (APOE) *E4 allele and Alzheimer's disease is very strong, the effect of the *E4 allele on cognitive decline in the general population is more equivocal. A cross-sectional study on the lifespan effects of the *E4 allele 1 failed to find any effect of the *E4 allele on cognitive performance at ages 20-24, 40-44 or 60-64 years. Methods. In this four year follow-up study, we reexamine the effect of *E4 in the sample of 2,021 individuals, now aged 65-69 years. Results. Performance on the Mini-Mental State Examination (MMSE) was significantly poorer for *E4 homozygotes than heterozygotes or non-carriers. The effects of the *E4 genotype on cognitive decline over four years were found on the MMSE and Symbol-Digit Modalities test but only when controlling for risk factors such as head injury and education. Analyses were repeated with the exclusion of participants diagnosed with a mild cognitive disorder, with little change. Conclusion. It is possible that *E4 carriers become vulnerable to greater cognitive decline in the presence of other risk factors at 65-69 years of age. © 2008 Christensen et al; licensee BioMed Central Ltd.

引用

共 35 条

[1] Jorm A.F., Mather K.A., Butterworth P., Anstey K.J., Christensen H., Easteal S., APOE genotype and cognitive functioning in a large age-stratified population sample, Neuropsychology, 21, 1, pp. 1-8, (2007)
[2] Ertekin-Taner N., Genetics of Alzheimer's Disease: A centennial review, Neurologic Clinics, 25, 3, pp. 611-67, (2007)
[3] Saunders A.M., Schmader K., Breitner J.C., Benson M.D., Brown W.T., Goldfarb L., Goldgaber D., Manwaring M.G., Szymanski M.H., McCown N., Dole K.C., Schmechel D.E., Strittmatter W.J., Pericak-Vance M.A., Roses A.D., Apolipoprotein e epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases, Lancet, 342, 8873, pp. 710-711, (1993)
[4] Crawford F.C., Vanderploeg R.D., Freeman M.J., Singh S., Waisman M., Michaels L., Abdullah L., Warden D., Lipsky R., Salazar A., Mullan M.J., APOE genotype influences acquisition and recall following traumatic brain injury, Neurology, 58, 7, pp. 1115-1118, (2002)
[5] Mukamal K.J., Kuller L.H., Fitzpatrick A.L., Longstreth Jr. W.T., Mittleman M.A., Siscovick D.S., Prospective study of alcohol consumption and risk of dementia in older adults, Journal of the American Medical Association, 289, 11, pp. 1405-1413, (2003)
[6] Johnston J.M., Nazar-Stewart V., Kelsey S.F., Kamboh M.I., Ganguli M., Relationships between cerebrovascular events, APOE polymorphism and Alzheimer's disease in a community sample, Neuroepidemiology, 19, 6, pp. 320-326, (2000)
[7] Schneider J.A., Bienias J.L., Wilson R.S., Berry-Kravis E., Evans D.A., Bennett D.A., The apolipoprotein e epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons, Stroke
[8] a Journal of Cerebral Circulation, 36, 5, pp. 954-959, (2005)
[9] Hofer S.M., Christensen H., MacKinnon A.J., Korten A.E., Jorm A.F., Henderson A.S., Easteal S., Change in cognitive functioning associated with apoE genotype in a community sample of older adults, Psychology and Aging, 17, 2, pp. 194-208, (2002)
[10] Small B.J., Basun H., Backman L., Three-year changes in cognitive performance as a function of apolipoprotein e genotype: Evidence from very old adults without dementia, Psychology and Aging, 13, 1, pp. 80-87, (1998)

← 1 2 3 4 →