Plasmodium falciparum: In vitro growth inhibition by febrile temperatures

被引：44

作者：

Bertrand L. ^{[1
,2
]}

机构：

[1] Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, 72074 Tubingen

[2] Department of Medical Biometry, University of Tübingen, 72070 Tubingen

来源：

Parasitology Research | 2001年 / 87卷 / 7期

关键词：

Malaria; Growth Inhibition; Plasmodium; Plasmodium Falciparum; Continuous Culture;

D O I：

10.1007/s004360100374

中图分类号：

学科分类号：

摘要：

Febrile episodes are the hallmark of malarial infection. We determined the inhibitory effect of febrile temperatures on the in vitro growth of Plasmodium falciparum. Parasites were cultured at various temperatures between 37°C and 40°C for 4 days. A logistic decrease in parasitaemia as a function of temperature was observed for continuous cultures. Incubation of synchronized cultures for different lengths of time during the parasite cycle showed a strong increase of growth inhibition with the maturing of parasites. Febrile temperatures inhibit parasite growth and long, high fevers during malaria may be beneficial for parasite clearance.

引用

页码：553 / 555

页数：2

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