FFAs: Do they play a role in vascular disease in the insulin resistance syndrome?

被引：29

作者：

Shankar S.S. ^{[1
]}

Steinberg H.O. ^{[1
]}

机构：

[1] Department of Medicine, Division of Endocrinology/Metabolism, Indiana University Medical Center, Indianapolis, IN 46202-5111

来源：

Current Diabetes Reports | 2005年 / 5卷 / 1期

关键词：

Nitric Oxide; Insulin Resistance; Free Fatty Acid; Nitric Oxide Production; Insulin Resistance Syndrome;

D O I：

10.1007/s11892-005-0064-6

中图分类号：

学科分类号：

摘要：

The insulin resistance syndrome, otherwise known as the metabolic syndrome, describes a cluster of cardiovascular and metabolic abnormalities, which are strongly associated with overweight and obesity. The importance of the syndrome is due to its increased rates of cardiovascular morbidity and mortality. Insulin resistance is also characterized by elevated free fatty acid, (FFA) levels. In otherwise healthy human subjects, elevation of FFA impairs endothelial function. This appears to be largely the result of blunting of nitric oxide-dependent tone, most likely at the level of the endothelial isoform of nitric oxide synthase (eNOS). Some of the potential mediatory mechanisms include oxidative stress, proinflammatory cytokines, C-reactive protein, or endogenous inhibitors of eNOS. Regardless of the mechanism(s) that mediates the effects of increased FFA on the vasculature, impaired vascular function is likely to account at least in part, for the increase in cardiovascular mortality in subjects with the insulin resistance syndrome. Copyright © 2005 by Current Science Inc.

引用

页码：30 / 35

页数：5

共 37 条

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