Genetic predictors of acute and chronic pain

被引：52

作者：

Edwards R.R. ^{[1
]}

机构：

[1] Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21287

来源：

Current Rheumatology Reports | 2006年 / 8卷 / 6期

关键词：

Pressure Pain Threshold; Genetic Predictor; Intervertebral Disc Disease; Congenital Insensitivity; Vulvar Vestibulitis;

D O I：

10.1007/s11926-006-0034-2

中图分类号：

学科分类号：

摘要：

Although broad agreement exists that genetic factors are important contributors to individual differences in pain sensitivity and risk for developing painful clinical conditions, the field of pain genetics is still in its infancy. This article reviews recent human studies of the genetics of acute and chronic pain, which implicate polymorphisms in genes coding for catechol-O-methyltransferase activity and μ-opioid receptors, among a number of others, as influential in explaining variability among the pain responses of individuals. Growing interest in pain genetics and accelerating methodologic advances in the field will almost certainly alter our understanding of which genes contribute to nociception and how dynamic interactions between multiple genes and environmental events shape the human experience of pain. Copyright © 2006 by Current Science Inc.

引用

页码：411 / 417

页数：6

共 37 条

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