NASH and the risk of cirrhosis and hepatocellular carcinoma in type 2 diabetes

被引：58

作者：

Bugianesi E. ^{[1
]}

Vanni E. ^{[1
]}

Marchesini G. ^{[1
]}

机构：

[1] Division of Gastro-Hepatology, University of Turin, S. Giovanni Battista Hospital, Turin 10126

来源：

Current Diabetes Reports | 2007年 / 7卷 / 3期

关键词：

Liver Disease; Fatty Liver; Chronic Liver Disease; NASH; Nonalcoholic Fatty Liver Disease;

D O I：

10.1007/s11892-007-0029-z

中图分类号：

学科分类号：

摘要：

The risk of chronic liver disease and liver-related mortality is increased in patients with type 2 diabetes mellitus. Several cohort studies have suggested a metabolic pathway from nonalcoholic fatty liver, nonalcoholic steatohepatitis, cryptogenic cirrhosis, and eventually hepatocellular carcinoma. Although cardiovascular risk remains the major cause for excess mortality in type 2 diabetes mellitus, the risk of progressive liver disease should no longer be underscored. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：175 / 180

页数：5

共 50 条

[1]

Falck-Ytter Y., Younossi Z.M., Marchesini G., Et al., Clinical features and natural history of nonalcoholic steatosis syndromes, Semin Liver Dis, 21, pp. 17-26, (2001)

[2]

Bellentani S., Saccoccio G., Masutti F., Et al., Prevalence of and risk factors for hepatic steatosis in Northern Italy, Ann Intern Med, 132, pp. 112-117, (2000)

[3]

Clark J.M., Brancati F.L., Diehl A.M., Nonalcoholic fatty liver disease, Gastroenterology, 122, pp. 1649-1657, (2002)

[4]

Marchesini G., Bugianesi E., Forlani G., Et al., Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome, Hepatology, 37, pp. 917-923, (2003)

[5]

Bugianesi E., McCullough A.J., Marchesini G., Insulin resistance: A metabolic pathway to chronic liver disease, Hepatology, 42, pp. 987-1000, (2005)

[6]

Browning J.D., Szczepaniak L.S., Dobbins R., Et al., Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity, Hepatology, 40, pp. 1387-1395, (2004)

[7]

Ricci C., Longo R., Gioulis E., Et al., Noninvasive in vivo quantitative assessment of fat content in human liver, J Hepatol, 27, pp. 108-113, (1997)

[8]

Mofrad P., Contos M.J., Haque M., Et al., Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values, Hepatology, 37, pp. 1286-1292, (2003)

[9]

Simo R., Hernandez C., Genesca J., Et al., High prevalence of hepatitis C virus infection in diabetic patients, Diabetes Care, 19, pp. 998-1000, (1996)

[10]

Gu K., Cowie C.C., Harris M.I., Mortality in adults with and without diabetes in a national cohort of the U.S. population, 1971-1993, Diabetes Care, 21, pp. 1138-1145, (1998)

← 1 2 3 4 5 →