N-hexanoyl chitosan stabilized magnetic nanoparticles: Implication for cellular labeling and magnetic resonance imaging

被引：52

作者：

Bhattarai S.R. ^{[1
]}

Kc R.B. ^{[2
]}

Kim S.Y. ^{[3
]}

Sharma M. ^{[3
]}

Khil M.S. ^{[4
]}

Hwang P.H. ^{[5
]}

Chung G.H. ^{[5
]}

Kim H.Y. ^{[4
]}

机构：

[1] Department of Pharmaceutical Sciences, Wayne State University, Detroit

[2] Department of Bionanosystem Engineering, Chonbuk National University, Jeonju

[3] Deparrtment of Pediatric and Clinical Research Center, School of Medicine, Chonbuk National University, Jeonju

[4] Department of Textile Engineering, Chonbuk National University, Jeonju

[5] Department of Radiology, School of Medicine, Chonbuk National University, Jeonju

来源：

Journal of Nanobiotechnology | / 6卷 / 1期

基金：

新加坡国家研究基金会;

关键词：

Chitosan; High Resolution Transmission Electron Microscopy; Dynamic Light Scattering; High Resolution Transmission Electron Microscopy; Iron Oxide Nanoparticles;

D O I：

10.1186/1477-3155-6-1

中图分类号：

学科分类号：

摘要：

This project involved the synthesis of N-hexanoyl chitosan or simply modified chitosan (MC) stabilized iron oxide nanoparticles (MC-IOPs) and the biological evaluation of MC-IOPs. IOPs containing MC were prepared using conventional methods, and the extent of cell uptake was evaluated using mouse macrophages cell line (RAW cells). MC-IOPs were found to rapidly associate with the RAW cells, and saturation was typically reached within the 24 h of incubation at 37°C. Nearly 8.53 ± 0.31 pg iron/cell were bound or internalized at saturation. From these results, we conclude that MC-IOPs effectively deliver into RAW cells in vitro and we also hope MC-IOPs can be used for MRI enhancing agents in biomedical fields. © 2008 Bhattarai et al; licensee BioMed Central Ltd.

引用

共 14 条

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