Plasma levels of the anti-inflammatory cytokine IL-10 and inflammatory cytokine IL-6 in patients with unstable angina

被引:7
作者
Hong Mei
Wei Wenning
Hu Yu
Yang Rui
Yang Yan
机构
[1] Huazhong University of Science and Technology,Institute of Haematology, Union Hospital, Tongji Medical College
来源
Journal of Huazhong University of Science and Technology [Medical Sciences] | 2005年 / 25卷 / 6期
关键词
unstable angina; interleukin-10; interleukin-6;
D O I
10.1007/BF02896157
中图分类号
学科分类号
摘要
The plasma levels of inflammatory cytokine interleukin-6 (IL-6) and anti-inflammatory cytokine interleukin-10 (IL-10) in the patients with unstable angina or stable angina were determined and compared. In 30 patients with unstable angina and 22 patients with stable angina, plasma levels of IL-10 and IL-6 were detected by ELISA and plasma lipid parameters by lipid research clinical methods respectively. The results showed plasma levels of IL-10 were significantly lower in unstable angina group than in stable angina group (P=0.005), while those of IL-6 were significantly increased in unstable angina group as compared with those in stable angina group (P=0.039). There was a significantly negative correlation between IL-10 and IL-6 in patients with unstable angina (r=−0.41,P=0.003). In the unstable angina group, IL-6 levels were obviously positively correlated with TC (r=0.314,P=0.023), but not with TG and HDL. There were no significant correlations between IL-10 and plasma lipid parameters. It was suggested that the decreased IL-10 and increased IL-6 might be associated with the atheromatous plaque stability and progression of coronary heart diseases. IL-10 may play an important role in preventing coronary vascular lesions.
引用
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页码:639 / 641
页数:2
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