Endothelial lipase and cholesterol metabolism

被引：18

作者：

Cilingiroglu M. ^{[1
]}

Ballantyne C. ^{[1
]}

机构：

[1] Sect. of Cardiology/Atherosclerosis, Baylor College of Medicine, Houston, TX 77030, One Baylor Plaza

来源：

Current Atherosclerosis Reports | 2004年 / 6卷 / 2期

关键词：

Lipase; Lipoprotein Lipase; Hepatic Lipase; Endothelial Lipase; Lipase Hydrolysis;

D O I：

10.1007/s11883-004-0101-y

中图分类号：

学科分类号：

摘要：

Endothelial lipase (EL), a new member of the lipase gene family, was recently cloned and has a significant role in plasma high-density lipoprotein levels (HDL). EL has a highly similar molecular homology to lipoprotein lipase and hepatic lipase. It is synthesized by endothelial cells and functions at the cell surface. EL primarily has phospholipase AI activity. Animals that overexpress EL showed decreased HDL cholesterol levels and those that lack EL show elevated levels of HDL cholesterol. The expression is highly regulated by cytokines and physical forces. These data suggest that EL may play a significant role in atherosclerosis. Copyright © 2004 by Current Science Inc.

引用

页码：126 / 130

页数：4

共 25 条

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