Nitric oxide and multiple sclerosis

被引：43

作者：

Encinas J.M. ^{[1
]}

Manganas L. ^{[1
]}

Enikolopov G. ^{[1
]}

机构：

[1] Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

来源：

Current Neurology and Neuroscience Reports | 2005年 / 5卷 / 3期

基金：

美国国家卫生研究院;

关键词：

Nitric Oxide; Multiple Sclerosis; Experimental Autoimmune Encephalomyelitis; Multiple Sclerosis Patient; Peroxynitrite;

D O I：

10.1007/s11910-005-0051-y

中图分类号：

学科分类号：

摘要：

Nitric oxide (NO) is a free radical signaling molecule with remarkably complex biochemistry. Its involvement in multiple sclerosis (MS) had been postulated soon after the discovery of the critical role NO plays in inflammation. However, the extent of NO's contribution to MS is not yet understood, party due to the often opposing roles that NO can play in cellular processes. This review briefly covers new developments in the area of NO that may be relevant to MS. It also describes recent progress in understanding the role of NO in MS, new potential targets of the action of NO in the cell, and prospects for NO-based therapies. Copyright © 2005 by Current Science Inc.

引用

页码：232 / 238

页数：6

共 61 条

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