Genetic and pathogenic insights into inflammatory bowel disease

被引：22

作者：

Francesco Pallone

Giovanna Del Vecchio Blanco

Piero Vavassori

Ivan Monteleone

Daniele Fina

Giovanni Monteleone

机构：

[1] Cattedra di Gastroenterologia, Dipartimento di Medicina Interna, Universita Tor Vergata di Roma, 00133 Rome

来源：

Current Gastroenterology Reports | 2003年 / 5卷 / 6期

关键词：

Inflammatory Bowel Disease; Ulcerative Colitis; CARD15 Gene; Lamina Propria Mononuclear Cell; CARD15 Mutation;

D O I：

10.1007/s11894-003-0038-2

中图分类号：

学科分类号：

摘要：

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the gastrointestinal tract that share clinical and pathologic characteristics. The most credible hypothesis is that CD and UC result from an inappropriate and exaggerated mucosal immune response to normal constituents of the mucosal microflora that is in part genetically determined. However. there is reason to believe that the main pathologic processes in these two diseases are distinct. For example, the CARD15/NOD2 gene has been identified as a susceptibility gene for CD but not for UC. Moreover, the study of patients and mouse models of inflammatory bowel disease has clearly shown that, in CD, the tissue-damaging inflammatory reaction is driven by interleukin-12-activated Th1 cells, whereas a humoral response predominates in UC. Copyright © 2003 by Current Science Inc.

引用

页码：487 / 492

页数：5

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