The genetics of depression and related traits

被引：19

作者：

Huezo-Diaz P. ^{[1
]}

Tandon K. ^{[1
]}

Aitchison K.J. ^{[1
]}

机构：

[1] MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London SE5 8AF, De Crespigny Park, Denmark Hill

来源：

Current Psychiatry Reports | 2005年 / 7卷 / 2期

关键词：

Panic Disorder; Harm Avoidance; Unipolar Depression; Early Life Stress; Linkage Disequi;

D O I：

10.1007/s11920-005-0008-5

中图分类号：

学科分类号：

摘要：

There is considerable evidence that genetic factors play a major role in the etiology of unipolar depression. Investigations into vulnerability genes for unipolar depression are underway and for more broadly defined depression-related traits, such as anxiety, neuroticism, and harm avoidance. This review discusses some of the core issues related to study design and molecular genetic methodology, followed by an overview of recent molecular genetic findings for unipolar depression. The research to date has identified regions within certain chromosomes that may contain risk genes. Improved study design and the use of new molecular techniques hold promise for the identification of more specific vulnerability genes for unipolar depression. Copyright © 2005 by Current Science Inc.

引用

页码：117 / 124

页数：7

共 67 条

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