Clinical implications of biomarkers in head and neck cancer.

被引：9

作者：

Koch W.M. ^{[1
]}

机构：

[1] Department of Otolaryngology-Head and Neck Surgery and Oncology, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, 21287-0910, MD

来源：

Current Oncology Reports | 1999年 / 1卷 / 2期

关键词：

Epidermal Growth Factor Receptor; Proliferate Cell Nuclear Antigen; Papillary Thyroid Carcinoma; Laryngeal Cancer; Neck Squamous Cell Carcinoma;

D O I：

10.1007/s11912-999-0023-5

中图分类号：

学科分类号：

摘要：

The term biomarker refers to a host of biologic factors found within a tumor or other clinical specimen that can be used to assess the tumor in some way. Biomarkers have many potential clinical applications. Before they are used in actual clinical settings, however, they must be carefully validated. The literature contains many reports of this ongoing work related to head and neck squamous cell carcinoma. Candidate biomarkers for this disease include the p53 gene and its protein; microsatellite regions throughout the genome; human papillomavirus; proteins involved in cellular proliferation, apoptosis, angiogenesis, and intracellular adhesion; epithelial growth factor receptor; and various measures of immune response to cancer. The best new evidence for the validity of each of these candidates is critiqued in this review.

引用

页码：129 / 137

页数：8

共 150 条

[1]

Ma L(1998)Clinical implication of screening p53 gene mutations in head and neck squamous cell carcinomas J Cancer Res Clin Oncol 124 389-396

[2]

Ronai A(1996)p53 mutation and locoregional treatment failure in head and neck squamous cell carcinoma J Natl Cancer Inst 88 1580-1586

[3]

Riede UN(1998)Is p53 an independent prognostic factor in patients with laryngeal carcinoma? Cancer 82 286-291

[4]

Koch WM(1998)Expression of bcl-2, p53 and Ki-67 and outcome of patients with primary nasopharyngeal carcinomas following DNA-damaging treatment Head Neck 20 640-644

[5]

Brennan JA(1998)The prognostic significance of the biomarkers p21WAF1/CIP1, p53 and bcl-2 in laryngeal squamous cell carcinoma Cancer 82 2159-2165

[6]

Zahurak M(1999)Prognostic significance of clinical parameters and biological markers in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy Clin Cancer Res 5 801-806

[7]

Narayana A(1998)Tumor proliferation, p53 expression, and apoptosis in laryngeal carcinoma: relation to the results of radiotherapy Cancer 83 2493-2501

[8]

Vaughan ATM(1998)p53 and bcl-2 expression in locally advanced squamous cell head-neck cancer treated with platinum based chemotherapy and radiotherapy Anticancer Res 18 4685-4692

[9]

Gunaratne S(1998)Ki-67 and p53 in T2 laryngeal cancer Laryngoscope 108 1548-1552

[10]

Masuda M(1998)p53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma J Pathol 184 360-368

← 1 2 3 4 5 6 7 8 9 10 →