An animal model for studying cone function in retinal detachment

被引：23

作者：

Jacobs G.H. ^{[1
,3
]}

Calderone J.B. ^{[1
,3
]}

Sakai T. ^{[2
]}

Lewis G.P. ^{[3
]}

Fisher S.K. ^{[4
]}

机构：

[1] Department of Psychology, Neuroscience Research Institute

[2] Neuroscience Research Institute, Department of Molecular, Cell and Developmental Biology, University of California, Santa Barbara

[3] Neuroscience Research Institute, Department of Ophthalmology, Jikei University School of Medicine, Tokyo

来源：

Documenta Ophthalmologica | 2002年 / 104卷 / 1期

关键词：

Cone; Cone-isolating stimuli; Electroretinogram; Ground squirrels; Retinal detachment;

D O I：

10.1023/A:1014431701523

中图分类号：

学科分类号：

摘要：

In people, retinal detachment often leads to a significant loss in cone-based vision. Most of the animal models commonly used for studying the consequences of retinal detachment have rod-dominated retinas. The purpose of this investigation was to evaluate the possibility that the ground squirrel, a rodent with a heavily cone-dominated retina, might provide a useful model for studying cone function in retinal detachment. Corneal ERGs were recorded from ground squirrels for large-field temporal modulations presented on a computer-controlled color monitor. Modulations were chosen to selectively stimulate either of the two classes of cone found in the ground squirrel retina. Under these test conditions, large and reliable cone ERGs could be readily recorded. In animals in which the retina had been surgically detached, the loss of cone signal was directly related to the number of cones in the detachment zone relative to the total cone population and that relationship did not differ for short-wavelength sensitive (S) and middle-wavelength sensitive (M) cones. Surgical reattachment produced a progressive recovery of cone-based signals. The ground squirrel seems likely to provide a useful animal model for studying the dynamics of cone function in retinal detachment and subsequent events.

引用

页码：119 / 132

页数：13

共 28 条

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