New biomedical strategies for HIV-1 prevention in women

被引:5
作者
Baeten J.M. [1 ]
机构
[1] Department of Global Health, University of Washington, Seattle, WA 98104
关键词
Bacterial Vaginosis; Male Circumcision; Biomedical Strategy; Intravaginal Practice; Topical Vaginal Microbicides;
D O I
10.1007/s11908-008-0080-1
中图分类号
学科分类号
摘要
Novel HIV-1 prevention strategies continue to be urgently needed. This article reviews the current state of biomedical prevention against HIV-1, focusing on recently completed and ongoing clinical trials of new prevention interventions, particularly those relevant to prevention of HIV-1 in women. Male circumcision, cervical barrier devices, suppressive therapy against herpes simplex virus type 2, treatment of vaginal infections and other vaginal health interventions, pre-exposure antiretroviral prophylaxis, and topical vaginal microbicides are discussed. © Current Medicine Group LLC 2008.
引用
收藏
页码:490 / 498
页数:8
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[1]  
2007 AIDS Epidemic Update: December 2007, (2008)
[2]  
Mbulaiteye S.M., Mahe C., Whitworth J.A., Et al., Declining HIV-1 incidence and associated prevalence over 10 years in a rural population in south-west Uganda: A cohort study, Lancet, 360, pp. 41-46, (2002)
[3]  
Cohen J., Did Mercks failed HIV vaccine cause harm?, Science, 318, pp. 1048-1049, (2007)
[4]  
Gray R.H., Wawer M.J., Brookmeyer R., Et al., Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda, Lancet, 357, pp. 1149-1153, (2001)
[5]  
Baeten J.M., Overbaugh J., Measuring the infectiousness of persons with HIV-1: Opportunities for preventing sexual HIV-1 transmission, Curr HIV Res, 1, pp. 69-86, (2003)
[6]  
Royce R.A., Sena A., Cates Jr. W., Cohen M.S., Sexual transmission of HIV, N Engl J Med, 336, pp. 1072-1078, (1997)
[7]  
Dunkle K.L., Stephenson R., Karita E., Et al., New heterosexually transmitted HIV infections in married or cohabitating couples in urban Zambia and Rwanda: An analysis of survey and clinical data, Lancet, 371, pp. 2183-2191, (2008)
[8]  
Auvert B., Taljaard D., Lagarde E., Et al., Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: The ANRS 1265 trial, PLoS Med, 2, (2005)
[9]  
Gray R.H., Kigozi G., Serwadda D., Et al., Male circumcision for HIV prevention in men in Rakai, Uganda: A randomised trial, Lancet, 369, pp. 657-666, (2007)
[10]  
Bailey R.C., Moses S., Parker C.B., Et al., Male circumcision for HIV prevention in young men in Kisumu, Kenya: A randomised controlled trial, Lancet, 369, pp. 643-656, (2007)