Challenges for vaccination in the elderly

被引：152

作者：

Aspinall R. ^{[1
]}

Del Giudice G. ^{[2
]}

Effros R.B. ^{[3
]}

Grubeck-Loebenstein B. ^{[4
]}

Sambhara S. ^{[5
]}

机构：

[1] Department of Immunology, Imperial College, London

[2] Novartis Vaccines, 53100 Siena

[3] Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA

[4] Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck

[5] Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA

来源：

Immunity & Ageing | / 4卷 / 1期

关键词：

Influenza; Telomere Length; West Nile Virus; Innate Immune System; Adaptive Immune System;

D O I：

10.1186/1742-4933-4-9

中图分类号：

学科分类号：

摘要：

The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naïve T cell population; alteration of the T cell population composition; modified phenotypes of individual T cells; and replicative senescence of memory cells expressing naïve markers. Unfortunately, immunosenescence also renders vaccination less effective in the elderly. It is therefore important that the vaccines used against common but preventable diseases, such as influenza, are specifically enhanced to overcome the reduced immune responsiveness of this vulnerable population. © 2007 Aspinall et al; licensee BioMed Central Ltd.

引用

共 49 条

[1]

World population ageing 1950-2050, Report Prepared for the 2nd World Assembly on Ageing, 2002, (2001)

[2]

Gavazzi G., Krause K.H., Ageing and infection, Lancet Infect Dis, 2, pp. 659-666, (2002)

[3]

Walford R.L., The Immunologic Theory of Aging, (1969)

[4]

McElhaney J.E., Overcoming the challenges of immunosenescence in the prevention of acute respiratory illness in older people, Conn Med, 67, pp. 469-474, (2003)

[5]

Cambier J., Immunosenescence: A problem of lymphopoiesis, homeostatsis, microenvironment and signalling, Immunol Rev, 205, pp. 5-6, (2005)

[6]

WHO position paper on Influenza vaccines, Wkly Epidemiol Rec WER, 33, pp. 279-287, (2005)

[7]

Goodwin K., Viboud C., Simonsen L., Antibody response to influenza vaccination in the elderly: A quantitative review, Vaccine, 24, pp. 1159-1169, (2006)

[8]

Renshaw M., Rockwell J., Engleman C., Gewirtz A., Katz J., Sambhara S., Cutting edge: Impaired toll-like receptor expression and function in aging, J Immunol, 169, pp. 4697-4701, (2002)

[9]

Katz J.M., Plowden J., Renshaw-Hoelscher M., Lu X., Tumpey T.M., Sambhara S., Immunity to influenza: The challenges of protecting an aging population, Immunol Res, 29, pp. 113-124, (2004)

[10]

van den Biggelaar A.H., Huizinga T.W., de Craen A.J., Gussekloo J., Heijmans B.T., Frolich M., Westendorp R.G., Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study, Exp Gerontol, 39, pp. 1407-1414, (2004)

← 1 2 3 4 5 →