Effect of cadmium on thyroid function in sheep

被引：9

作者：

Badiei K. ^{[1
]}

Nikghadam P. ^{[1
]}

Mostaghni K. ^{[1
]}

机构：

[1] Department of Clinical Studies, School of Veterinary Medicine, Shiraz 71345

来源：

Comparative Clinical Pathology | 2009年 / 18卷 / 3期

关键词：

Cadmium; Sheep; Thyroid function;

D O I：

10.1007/s00580-008-0785-4

中图分类号：

学科分类号：

摘要：

The objective of this experiment was to determine the effect of long-term low-dose administration of cadmium on thyroid function in sheep. In this experiment, ten healthy Iranian male sheep, aged about 1 year old, were randomly allocated into two equal groups of control (n = 5) and experiment (n = 5). Both groups were kept under the same conditions of food and environment. Treatment group received cadmium chloride (1 mg/kg/day) orally for 8 weeks. Blood sampling of two groups was done on days 0, 14, 28, 42, 56, and 70 every morning (8 to 9 a.m.). The function of the thyroid was evaluated by measuring the levels of serum thyroid hormones T3, T4, FT3, FT4, and TSH. The hepatic function in both groups was evaluated by measuring hepatic enzyme activities including alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ glutamyl transferase (GGT), and total bilirubin (TBIL). Serum levels of T3, T4, FT3, FT4, and TSH significantly decreased in cadmium-treated sheep when compared to control group (p < 0.05). Serum enzyme activities of ALT, AST, GGT, and TBIL in Cd-treated sheep were significantly increased in comparison with control group (p < 0.05). Our findings suggest that Cd-exposed sheep can be at a risk of low thyroid function. © Springer-Verlag London Limited 2008.

引用

页码：255 / 259

页数：4

共 33 条

[1]

Beers M.H., Berkow R., The Merck Manual of Diagnosis and Therapy, (1999)

[2]

Berlin M., Ullberg S., The fate of Cd109 in the mouse, Arch Environ Health, 7, (1963)

[3]

Chan D.Y., Fry N., Waisberg M., Black W.D., Hale B.A., Accumulation of dietary cadmium (Cd) in rabbit tissues and excretions: A comparison of lettuce amended with soluble Cd salt and lettuce with plant-incorporated Cd, J Toxicol Environ Health, 67, pp. 397-411, (2004)

[4]

Chapman T.L., Genetic Heavy Metal Toxicity: Explaining SIDS, Autism, Tourette's, Alzheimer's and Other Epidemics, (2008)

[5]

Chaurasia S.S., Gupta P., Kar A., Maiti P.K., Free radical mediated membrane perturbation and inhibition of type-I iodothyronine 5′-monodeiodinase activity by lead and cadmium in rat liver homogenate, Biochem Mol Biol Int, 39, pp. 765-770, (1996)

[6]

De Wolf H., Backeljau T., Blust R., Sensitivity to cadmium along a salinity gradient in populations of the periwinkle, Aquat Toxicol, 66, pp. 241-253, (2004)

[7]

Gibney M.J., MacDonald I.A., Roche H.M., Nutrition and Metabolism (The Nutrition Society Textbook), (2003)

[8]

Gupta P., Chaurasia S.S., Maiti P.K., Kar A., Cadmium induced alterations in extrathyroidal conversion of thyroxine to triiodothyronine by type-I iodothyronine 5′-monodeiodinase in male mouse, Horm Metab Res, 29, pp. 151-152, (1997)

[9]

Gupta P., Kar A., Cadmium induced thyroid dysfunction in chicken: Hepatic type I iodothyronine 5′-monodeiodinase activity and role of lipid peroxidation, Comp Biochem Physiol, 123, pp. 39-44, (1999)

[10]

Higgins C., Understanding Laboratory Investigations for Nurses and Health Professionals, (2007)

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