The antiphospholipid syndrome and atherosclerosis: clue to pathogenesis.

被引：8

作者：

Joan T. Merrill

机构：

[1] Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, 73104, OK

来源：

Current Rheumatology Reports | 2003年 / 5卷 / 5期

关键词：

Systemic Lupus Erythematosus; Complement Activation; Acute Phase Response; Arterioscler Thromb Vasc Biol; Free Protein;

D O I：

10.1007/s11926-003-0032-6

中图分类号：

学科分类号：

摘要：

Regulation of blood vessels is intrinsically tied to inflammatory signaling. Recent research suggests that chronic inflammation is associated with atherosclerosis risk. The antiphospholipid syndrome is a prototypic autoimmune disease. Disturbance of blood vessel homeostasis in this disorder may increase risk for atherosclerosis by mechanisms that are direct (through antibody targeting of blood vessel-regulating proteins) or indirect (via inflammatory mechanisms that have recently been implicated in autoantibody-mediated thrombosis).

引用

页码：401 / 406

页数：5

共 272 条

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