Carotid plaque compared with intima-media thickness as a predictor of coronary and cerebrovascular disease

被引：40

作者：

Johnsen S.H. ^{[1
]}

Mathiesen E.B. ^{[1
]}

机构：

[1] Department of Neurology, University Hospital North Norway, N-9038 Breivika, Tromsø

来源：

Current Cardiology Reports | 2009年 / 11卷 / 1期

关键词：

Carotid Stenosis; Carotid Plaque; Pitavastatin; Plaque Area; Total Plaque Area;

D O I：

10.1007/s11886-009-0004-1

中图分类号：

学科分类号：

摘要：

Atherosclerosis is the underlying cause of most myocardial infarction (MI) and ischemic strokes. B-mode ultrasound of carotid arteries provides measures of intima-media thickness (IMT) and plaques, both widely used as surrogate measures of cardiovascular disease. Although IMT and plaques are highly intercorrelated, IMT's role as a marker of atherosclerosis has been questioned, especially when measurements include the common carotid artery (CCA) only. Plaque and intima-media thickening may reflect different biological aspects of atherogenesis with distinctive relations to clinical vascular disease. Plaque measured in the carotid bulb or internal carotid artery is stronger related to hyperlipidemia and smoking and is a stronger predictor for MI, whereas CCA-IMT is stronger related to hypertension and ischemic stroke. Echolucent plaque morphology (ie, lipid-rich plaques) seems to increase the risk for MI and stroke. New evidence suggests that total plaque area is the most strongly predictive of cardiovascular risk of the ultrasound phenotypes. © 2009 by Current Medicine Group LLC.

引用

页码：21 / 27

页数：6

共 51 条

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