Omega-3 fatty acids, acute coronary syndrome, and sudden death

被引：8

作者：

Harris W.S. ^{[1
]}

von Schacky C. ^{[1
]}

机构：

[1] Nutrition and Metabolic Disease Research Center, Sanford School of Medicine of the University of South Dakota, Sioux Falls, SD, 57105

来源：

Current Cardiovascular Risk Reports | 2008年 / 2卷 / 2期

关键词：

Heart Rate Variability; Sudden Cardiac Death; Heart Outcome Prevention Evaluation; Heart Protection Study; Nonfatal Event;

D O I：

10.1007/s12170-008-0029-9

中图分类号：

学科分类号：

摘要：

Omega-3 fatty acids (FAs) are currently recommended to reduce the risk of cardiovascular diseases. These recommendations are based on randomized trials, prospective cohort studies, and case-control data and are supported by experimental studies in humans, animals, and isolated cells. Raising tissue levels of omega-3 FAs reduces the risk of sudden cardiac death, most likely due to reduced susceptibility to fatal arrhythmias, but the effect of these FAs on the risk of myocardial infarction per se is less clear. Reductions in nonfatal events have not typically been seen in randomized trials, but case-control and prospective cohort studies support such an effect. Future studies should assess tissue levels of omega-3 FAs to more precisely estimate exposure and to more clearly define the relations between omega-3 status and the risk of fatal or nonfatal cardiovascular diseases. © 2008 Current Medicine Group LLC.

引用

页码：161 / 166

页数：5

共 50 条

[1]

Kris-Etherton P.M., Harris W.S., Appel L.J., Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease, Circulation, 106, pp. 2747-2757, (2002)

[2]

Smith Jr. S.C., Allen J., Blair S.N., Et al., AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute, Circulation, 113, pp. 2363-2372, (2006)

[3]

Priori S.G., Aliot E., Blomstrom-Lundqvist C., Et al., Update of the guidelines on sudden cardiac death of the European Society of Cardiology, Eur Heart J, 24, pp. 13-15, (2003)

[4]

van de Werf F., Ardissino D., Betriu A., Et al., Management of acute myocardial infarction in patients presenting with ST-segment elevation. The Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology, Eur Heart J, 24, pp. 28-66, (2003)

[5]

Wang C., Harris W.S., Chung M., Et al., n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary-and secondary-prevention studies: a systematic review, Am J Clin Nutr, 84, pp. 5-17, (2006)

[6]

Albert C.M., Campos H., Stampfer M.J., Et al., Blood levels of long-chain n-3 fatty acids and the risk of sudden death, N Engl J Med, 346, pp. 1113-1118, (2002)

[7]

Burr M.L., Fehily A.M., Gilbert J.F., Et al., Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART), Lancet, 2, pp. 757-761, (1989)

[8]

Burr M.L., Ashfield-Watt P.A., Dunstan F.D., Et al., Lack of benefit of dietary advice to men with angina: results of a controlled trial, Eur J Clin Nutr, 57, pp. 193-200, (2003)

[9]

Geleijnse J.M., Brouwer I.A., Feskens E.J., Risks and benefits of omega 3 fats: health benefits of omega 3 fats are in doubt, Bmj, 332, pp. 915-916, (2006)

[10]

Marchioli R., Barzi F., Bomba E., Et al., Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione, Circulation, 105, pp. 1897-1903, (2002)

← 1 2 3 4 5 →