Regulatory T cells in rheumatoid arthritis

被引:11
作者
Sarkar S. [1 ]
Fox D.A. [1 ]
机构
[1] Division of Rheumatology, Ann Arbor, MI 48109-5358
基金
美国国家卫生研究院;
关键词
Rheumatoid Arthritis; Rheumatoid Arthritis Patient; Th17 Cell; Transform Growth Factor; Treg Cell;
D O I
10.1007/s11926-008-0065-y
中图分类号
学科分类号
摘要
Regulatory T cells have attracted substantial interest in connection with their role in controlling autoimmunity and the possibility that they could be used therapeutically. Here, we summarize the current understanding of the several subsets of regulatory T cells and defects in their function in rheumatoid arthritis. In evaluating the possibility of using regulatory T cells to treat rheumatoid arthritis, the relationship between these cells and the development and function of Th17 cells must be understood fully. © Springer Science+Business Media, LLC 2008.
引用
收藏
页码:405 / 412
页数:7
相关论文
共 84 条
[1]
Gershon R.K., Kondo K., Cell interactions in the induction of tolerance: The role of thymic lymphocytes, Immunology, 18, pp. 723-737, (1970)
[2]
Sakaguchi S., Sakaguchi N., Asano M., Et al., Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, J Immunol, 155, pp. 1151-1164, (1995)
[3]
Asano M., Toda M., Sakaguchi N., Sakaguchi S., Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation, J Exp Med, 184, pp. 387-396, (1996)
[4]
Itoh M., Takahashi T., Sakaguchi N., Et al., Thymus and autoimmunity: Production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance, J Immunol, 162, pp. 5317-5326, (1999)
[5]
Suri-Payer E., Amar A., McHugh R., Et al., Post-thymectomy autoimmune gastritis: Fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells, Eur J Immunol, 29, pp. 669-677, (1999)
[6]
Schorle H., Holtschke T., Huenig T., Et al., Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting, Nature, 352, pp. 621-624, (1991)
[7]
Setoguchi R., Hori S., Takahashi T., Sakaguchi S., Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization, J Exp Med, 201, pp. 723-735, (2005)
[8]
Suzuki H., Zhou Y.W., Kato M., Et al., Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo, J Exp Med, 190, pp. 1561-1572, (1999)
[9]
Malek T.R., Yu A., Vincek V., Et al., CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2, Immunity, 17, pp. 167-178, (2002)
[10]
Takahashi T., Kuniyasu Y., Toda M., Et al., Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state, Int Immunol, 10, pp. 1969-1980, (1998)