Vascular failure: A hypothesis

被引：8

作者：

Stephen M. Schwartz

Randolph L. Geary

Lawrence D. Adams

机构：

[1] Department of Pathology, University of Washington, School of Medicine, Seattle

来源：

Current Atherosclerosis Reports | 2003年 / 5卷 / 3期

关键词：

Vascular Remodel; Myosin Light Chain Kinase; Coronary Artery Spasm; Arterial Remodel; Accessory Domain;

D O I：

10.1007/s11883-003-0025-y

中图分类号：

学科分类号：

摘要：

Although cardiac failure has been studied extensively, vascular failure is not a recognizable term. We suggest that it is reasonable to argue that failure of the vessel to control its mass, contractile capacity, and lumen will involve pathways similar to cardiac failure. Vascular failure, or perhaps more accurately arterial failure, has very different consequences. Failure to control mass and external diameter will result in hypertension or loss af lumen in atherosclerosis. We review what is known about this normal remodeling response and its failure, and propose directions for research. Copyright © 2003 by Current Science Inc.

引用

页码：201 / 207

页数：6

共 51 条

[1] Wolinsky H., Glagov S., A lamellar unit of aortic medial structure and function in mammals, Circ. Res., 20, pp. 99-101, (1967)
[2] Glagov S., Weisenberg E., Zarins C.K., Et al., Compensatory enlargement of human atherosclerotic coronary arteries, N. Engl. J. Med., 316, pp. 1371-1375, (1987)
[3] Folkow B., Physiological aspects of primary hypertension, Physiol. Rev., 62, pp. 347-504, (1982)
[4] Cho A., Mitchell L., Koopmans D., Langille B.L., Effects of changes in blood flow rate on cell death and cell proliferation in carotid arteries of immature rabbits, Circ. Res., 81, pp. 328-337, (1997)
[5] Mulvany M.J., Hansen P.K., Aalkjaer C., Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth muscle cell layers, Circ. Res., 43, pp. 854-863, (1978)
[6] Mulvany M.J., Resistance vessel growth and remodeling: Cause or consequence in cardiovascular disease, J. Hum. Hypertens., 9, pp. 479-485, (1995)
[7] Bray P., Agrotis A., Bobik A., Transforming growth factor-beta and receptor tyrosine kinase-activating growth factors negatively regulate collagen genes in smooth muscle of hypertensive rats, Hypertension, 31, pp. 986-994, (1998)
[8] Bezie Y., Lamaziere J.M., Laurent S., Et al., Fibronectin expression and aortic wall elastic modulus in spontaneously hypertensive rats, Arterioscler. Thromb. Vasc. Biol., 18, pp. 1027-1034, (1998)
[9] Himeno H., Crawford D.C., Hosoi M., Et al., Angiotensin II alters aortic fibronectin independently of hypertension, Hypertension, 23, pp. 823-826, (1994)
[10] Deindl E., Buschmann I., Hoefer I.E., Et al., Role of ischemia and of hypoxia-inducible genes in arteriogerlesis after femoral artery occlusion in the rabbit, Circ. Res., 89, pp. 779-786, (2001)

← 1 2 3 4 5 6 →