Paracrine activity of multipotent mesenchymal stromal cells and its modulation in hypoxia

被引：4

作者：

Andreeva E.R. ^{[1
]}

Buravkova L.B. ^{[1
]}

机构：

[1] Institute of Biomedical Problems, Russian Academy of Sciences, Moscow

来源：

Human Physiology | 2013年 / 39卷 / 3期

基金：

俄罗斯基础研究基金会;

关键词：

hypoxia; multipotent mesenchymal stromal cells (MMSCs); paracrine mediators;

D O I：

10.1134/S0362119713030043

中图分类号：

学科分类号：

摘要：

Multipotent mesenchymal stromal (stem) cells (MMSCs) play an important role in the structural and functional balance in tissues and reparative remodeling. The wide range of soluble mediators synthesized by cMMSCs includes molecules with immunomodulatory, antiapoptotic, proangiogenic, supportive chemoattractive, and other effects. Microenvironmental factors, such as cell-to-cell contacts, the connective tissue matrix, and partial oxygen pressure, can significantly affect the profile of paracrine mediators synthesized by MMSCs and, respectively, change their biological activity. This review analyzes the recent data on the paracrine activity of MMSCs and its modulation in hypoxia, which is specific for their physiological tissue niches. © 2013 Pleiades Publishing, Ltd.

引用

页码：315 / 322

页数：7

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