Regulation of sodium/potassium ATPase activity: Impact on salt balance and vascular contractility

被引：30

作者：

Aperia A. ^{[1
]}

机构：

[1] Department of Women and Child Health, Karolinska Institutet

来源：

Current Hypertension Reports | 2001年 / 3卷 / 2期

关键词：

Dopamine; ATPase Activity; Ouabain; Atrial Natriuretic Peptide; Cytoskeleton Protein;

D O I：

10.1007/s11906-001-0032-8

中图分类号：

学科分类号：

摘要：

Na+,K+-ATPase distributes ions between the intracellular and extracellular space and is responsible for total-body sodium homeostasis. The activity of this ion pump is regulated by catecholamines and peptide hormones; by the ligand of Na+,K+-ATPase, ouabain; and by direct interaction with cytoskeleton proteins. This review summarizes recent advances in the field of short-term regulation of Na+,K+- ATPase and the implications of these advances for the regulation of blood pressure. Renal Na+,K+-ATPase activity is bidirectionally regulated by natriuretic and antinatriuretic hormones, and a shift in the balance between these forces may lead to salt retention and hypertension. Dopamine plays a key role in this interactive regulation. By inhibiting vascular Na +,K+-ATPase activity, an excess of circulating ouabain may increase calcium concentration in vascular cells and lead to increased vascular contractility. Finally, mutations in cytoskeleton proteins may stimulate renal Na+,K+-ATPase activity by way of protein/protein interaction and lead to salt retention and hypertension. Abnormalities in the systems regulating Na+,K+-ATPase should be explored further in the search for the multiple causes of essential hypertension. Copyright © 2001 by Current Science Inc.

引用

页码：165 / 171

页数：6

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