Hyperglucagonemia in an animal model of insulin- deficient diabetes: what therapy can improve it?

[1] Del Prato S(2004)Beta- and alpha-cell dysfunction in type 2 diabetes Horm Metab Res 36 775-81

[2] Marchetti P(2009)HOMA-beta in the UKPDS and ADOPT. Is the natural history of type 2 diabetes characterised by a progressive and inexorable loss of insulin secretory function? Maybe? Maybe not? Diab Vasc Dis Res 6 133-8

[3] Reaven GM(2014)Beta-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment J Clin Endocrinol Metab 99 1983-92

[4] Halban PA(2008)Too much glucagon, too little insulin: time course of pancreatic islet dysfunction in new-onset type 1 diabetes Diabetes Care 31 1403-4

[5] Polonsky KS(2014)The role of glucagon on type 2 diabetes at a glance Diabetol Metab Syndr 6 91-18

[6] Bowden DW(2015)INS-gene mutations: from genetics and beta cell biology to clinical disease Mol Aspects Med 42 3-9

[7] Hawkins MA(2010)Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of Youth Trends Endocrinol Metab 21 652-37

[8] Ling C(1999)A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse J Clin Invest 103 27-76

[9] Mather KJ(2007)Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice Diabetes 56 1268-4

[10] Powers AC(2007)Insulin gene mutations as a cause of permanent neonatal diabetes Proc Natl Acad Sci U S A 104 15040-56

[1] Del Prato S(2004)Beta- and alpha-cell dysfunction in type 2 diabetes Horm Metab Res 36 775-81

[2] Marchetti P(2009)HOMA-beta in the UKPDS and ADOPT. Is the natural history of type 2 diabetes characterised by a progressive and inexorable loss of insulin secretory function? Maybe? Maybe not? Diab Vasc Dis Res 6 133-8

[3] Reaven GM(2014)Beta-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment J Clin Endocrinol Metab 99 1983-92

[4] Halban PA(2008)Too much glucagon, too little insulin: time course of pancreatic islet dysfunction in new-onset type 1 diabetes Diabetes Care 31 1403-4

[5] Polonsky KS(2014)The role of glucagon on type 2 diabetes at a glance Diabetol Metab Syndr 6 91-18

[6] Bowden DW(2015)INS-gene mutations: from genetics and beta cell biology to clinical disease Mol Aspects Med 42 3-9

[7] Hawkins MA(2010)Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of Youth Trends Endocrinol Metab 21 652-37

[8] Ling C(1999)A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse J Clin Invest 103 27-76

[9] Mather KJ(2007)Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice Diabetes 56 1268-4

[10] Powers AC(2007)Insulin gene mutations as a cause of permanent neonatal diabetes Proc Natl Acad Sci U S A 104 15040-56