Pregnant women become insensitive to cold stress

被引：139

作者：

Kammerer M. ^{[1
]}

Adams D. ^{[2
]}

von Castelberg B. ^{[3
]}

Glover V. ^{[2
]}

机构：

[1] University of Zurich, KJPD, Regionalstelle Horgen, CH 8810 Horgen

[2] Wolfson/Weston Res. Ctr. Fam. Hlth, Institute of Repro./Devmtl. Biology, Imperial College, London W12 0NN, Hammersmith Campus, Du Cane Road

[3] Klinik fur Gynakologie/Geburtshilfe, Maternité Inselhof Triemli, CH 8063 Zürich

来源：

BMC Pregnancy and Childbirth | / 2卷 / 1期

关键词：

Cortisol; Cortisol Level; Postpartum Period; Cortisol Response; Postpartum Woman;

D O I：

10.1186/1471-2393-2-8

中图分类号：

学科分类号：

摘要：

Background: The function of the hypothalamic-pituitary-adrenal (HPA) axis is known to be altered during pregnancy, but it has not been tested with a natural stressor. Methods: A group of pregnant women (n = 10) were tested towards the end of pregnancy (mean 36.8 ± 2.5 weeks gestation) and about 8 weeks postpartum (mean 7.8 ± 1.5 weeks), together with a matched control group, with a one minute cold hand stressor test. Saliva samples were collected before and 10 and 20 minutes after the test, and stored for later radioimmunoassay of cortisol. Results: The control group showed a highly significant response to the test. The pregnant group showed no response, and the postpartum group a variable but non significant one Conclusions: This shows that the HPA axis becomes hypofunctional to a natural stressor at the end of pregnancy. It is suggested that one possible evolutionary function for this is to protect the fetus from the stress responses of the mother. © Kammerer et al; licensee BioMed Central Ltd.

引用

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