The glycemic index and cardiovascular disease risk

被引：51

作者：

Brand-Miller J. ^{[1
]}

Dickinson S. ^{[1
]}

Barclay A. ^{[1
]}

Celermajer D. ^{[1
]}

机构：

[1] Human Nutrition Unit (G08), University of Sydney, Camperdown

来源：

Current Atherosclerosis Reports | 2007年 / 9卷 / 6期

关键词：

Acarbose; Glycemic Index; Glycemic Load; Glycaemic Index; Postprandial Glycemia;

D O I：

10.1007/s11883-007-0064-x

中图分类号：

学科分类号：

摘要：

Postprandial hyperglycemia is increasingly recognized as an independent risk factor for cardiovascular disease. Glycemic "spikes" may adversely affect vascular structure and function via multiple mechanisms, including (acutely and/or chronically) oxidative stress, inflammation, low-density lipoprotein oxidation, protein glycation, and procoagulant activity. Postprandial glycemia can be reliably predicted by considering both the amount and type of carbohydrate. In particular, the glycemic index (GI), a measure of postprandial glycemic potency weight for weight of carbohydrate, has provided insights that knowledge of the sugar or starch content has not. In prospective observational studies, dietary GI and/or glycemic load independently predict cardiovascular disease, with relative risk ratios of 1.2 to 1.7 comparing highest and lowest quintiles. In randomized controlled trials in overweight subjects, diets based on low-GI carbohydrates have produced better cardiovascular-related outcomes than conventional low-fat diets. Taken together, the findings suggest that health professionals may be able to improve cardiovascular outcomes by recommending the judicious use of low-GI/glycemic load foods. Copyright © 2007 by Current Medicine Group LLC.

引用

页码：479 / 485

页数：6

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