Comparison of functional annotation schemes for genomes

被引：2

作者：

Rison S.C.G. ^{[1
,2
]}

Hodgman T.C. ^{[3
]}

Thornton J.M. ^{[2
,4
]}

机构：

[1] Ludwig Institute for Cancer Research, London, W1P 8BT

[2] Department of Biochemistry and Molecular Biology, University College London, London, WC1E 6BT, Gower Street

[3] Global Research Information Systems, Glaxo Wellcome Medicines Research Centre, Stevenage, SG1 2NY, Gunnels Wood Road

[4] Department of Crystallography, Birkbeck College, London, WC1E 7HX, Malet Street

来源：

Functional & Integrative Genomics | 2000年 / 1卷 / 1期

关键词：

Functional genomics; Gene product classification; Ontology; Protein function;

D O I：

10.1007/s101420000005

中图分类号：

学科分类号：

摘要：

In this paper we survey a number of functional classification schemes applicable to genomes. We present the concepts of depth, breadth and resolution as descriptors of the schemes' scope and architecture and compare selected classifications according to these criteria. We also generate a 'Combined Scheme' against which we map six classifications which we believe are representative of the range currently available. The mapping allows the generation of 'FuncWheels', which are graphical representations of hierarchical classification schemes. They are used to illustrate similarities and differences in functional space coverage. This survey highlights many issues related to the design and implementation of gene product functional classifications, which are discussed in the light of emerging 'second-generation' schemes. © Springer-Verlag 2000.

引用

页码：56 / 69

页数：13

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