Bench-to-bedside review: Genetic influences on meningococcal disease

被引:13
作者
Vermont C.L. [1 ]
de Groot R. [1 ]
Hazelzet J.A. [1 ]
机构
[1] Sophia Children's Hospital, Rotterdam
来源
Critical Care | / 6卷 / 1期
关键词
Genetic polymorphisms; Meningococcal sepsis; Review;
D O I
10.1186/cc1454
中图分类号
学科分类号
摘要
This review discusses the possible involvement of a variety of genetic polymorphisms on the course of meningococcal disease. It has been shown that several common genetic polymorphisms can either influence the susceptibility to meningococcal disease or can account for a higher mortality rate in patients. Gene polymorphisms concerning antibody receptors, lipopolysaccharide (LPS) binding receptors or proteins, innate complement proteins as well as cytokines and hemostatic proteins are described. The study of genetic polymorphisms might provide important insights in the pathogenesis of meningococcal disease and could make it possible to identify individuals who are at risk of either contracting or dying from meningococcal disease.
引用
收藏
页码:60 / 65
页数:5
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  • [1] Rosenstein N.E., Perkins B.A., Stephens D.S., Popovic T., Hughes J.M., Meningococcal disease, N. Engl. J. Med., 344, pp. 1378-1388, (2001)
  • [2] Sim R.J., Harrison M.M., Moxon E.R., Tang C.M., Underestimation of meningococci in tonsillar tissue by nasopharyngeal swabbing, Lancet, 356, pp. 1653-1654, (2000)
  • [3] Fogarty I., Cafferkey M.T., Moloney A.C., Meningococcal disease in the Republic of Ireland: 1995, Commun. Dis. Rep. CDR Rev., 7, (1997)
  • [4] Bacterial Meningitis in the Netherlands. Annual Report 1999, (2001)
  • [5] Sorensen T.I., Nielsen G.G., Andersen P.K., Teasdale T.W., Genetic and environmental influences on premature death in adult adoptees, N. Engl. J. Med., 318, pp. 727-732, (1988)
  • [6] Kwiatkowski D., Genetic dissection of the molecular pathogenesis of severe infection, Intensive Care Med., 26, SUPPL. 1, (2000)
  • [7] Kallstrom H., Liszewski M.K., Atkinson J.P., Jonsson A.B., Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria, Mol. Microbiol., 25, pp. 639-647, (1997)
  • [8] Virji M., Alexandrescu C., Ferguson D.J., Saunders J.R., Moxon E.R., Variations in the expression of pili: The effect on adherence of Neisseria meningitidis to human epithelial and endothelial cells, Mol. Microbiol., 6, pp. 1271-1279, (1992)
  • [9] Virji M., Makepeace K., Ferguson D.J., Watt S.M., Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriae, Mol. Microbiol., 22, pp. 941-950, (1996)
  • [10] de Vries F.P., Cole R., Dankert J., Frosch M., van Putten J.P., Neisseria meningitidis producing the Opc adhesin binds epithelial cell proteoglycan receptors, Mol. Microbiol., 27, pp. 1203-1212, (1998)