Bio-resorbable nanoceramics for gene and drug delivery

被引：80

作者：

Kriven W.M. ^{[1
]}

Kwak S.-Y. ^{[1
]}

Wallig M.A. ^{[2
]}

Choy J.-H. ^{[3
]}

机构：

[1] Dept. of Mat. Science and Eng., Univ. Illinois at Urbana-Champaign, Urbana, IL

[2] Dept. of Veterinary Pathobiology, Univ. Illinois at Urbana-Champaign, Urbana, IL

[3] School of Chem. Molecular Eng., Seoul National University, Seoul

来源：

MRS Bulletin | 2004年 / 29卷 / 1期

关键词：

Biomedical materials; Ceramics; Drug delivery; Intercalation; Nonviral vectors; Safety studies; Scanning electron microscopy (SEM); Transmission electron microscopy (TEM);

D O I：

10.1557/mrs2004.14

中图分类号：

学科分类号：

摘要：

Nanoscale ceramic particles, such as layered double hydroxides (LDHs), have been developed to deliver drugs or genes into biological cells. In this article, we describe the controlled-release properties of LDHs as drug delivery carriers, the formation of bio-LDH nanohybrids, their in vivo and in vitro cytotoxicity tests, and their potential as anticancer gene delivery carriers. Unstable biomolecules can be intercalated into LDHs, displacing the interlayer anions; the drug or gene's negative charge is thus shielded, enabling penetration into the cell. In the slightly acidic environment of the cell, ceramic nanoplatelets of ∼100 nm diameter dissolve, thus releasing the intercalates in a controlled manner.

引用

页码：33 / 37

页数：4

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