Β-Adrenergic blocking drugs as antifibrillatory agents

被引：11

作者：

Reiter M. ^{[1
]}

机构：

[1] Division of Cardiology, University of Colorado Health Service Center, Denver, CO 80262

来源：

Current Cardiology Reports | 2002年 / 4卷 / 5期

关键词：

Metoprolol; Sudden Death; Carvedilol; Flecainide; Esmolol;

D O I：

10.1007/s11886-002-0043-3

中图分类号：

学科分类号：

摘要：

p-Adrenergic blockade is associated with a significant reduction in mortality in most patients with structural heart disease. Clinical trial data involving patients after myocardial infarction or with congestive heart failure demonstrate that a reduction in sudden death accounts for much of the observed mortality reduction, p-adrenergic blockade inhibits the proarrhythmic effects of both neural and humoral sympathetic stimulation and inhibits the vagal withdrawal that accompanies ischemia. Although it does not have a dramatic effect on spontaneous ectopy or inducible monomorphic ventricular tachycardia, experimental and clinical data suggest that it inhibits the development of ventricular fibrillation by several mechanisms. Copyright © 2002 by Current Science Inc.

引用

页码：426 / 433

页数：7

共 63 条

[1]

Luu M., Stevenson W.G., Stevenson L.W., Et al., Diverse mechanisms of unexpected cardiac arrest in advanced heart failure, Circulation, 80, pp. 1675-1680, (1989)

[2]

Kendall M.J., Lynch K.P., Hjalmarson A., Kjekshus J., Beta-blockers and sudden cardiac death, Ann Intern Med, 123, pp. 358-367, (1995)

[3]

Olsson G., Tuomilehto J., Berglund G., Et al., Primary prevention of sudden cardiovascular death in hypertensive patients. Mortality results from the maphy study, Am J Hypertens, 4, pp. 151-158, (1991)

[4]

A randomized trial of propranolol in patients with acute myocardial infarction: I. Mortality results, JAMA, 247, pp. 1707-1714, (1982)

[5]

Chadda K., Goldstein S., Byington R., Curb J.D., Effect of propranolol after acute myocardial infarction in patients with congestive heart failure, Circulation, 73, pp. 503-510, (1986)

[6]

Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction, N Engl J Med, 304, pp. 801-807, (1981)

[7]

Comparison of invasive and conservative strategies after treatment with intravenous tissue plasminogen activator in acute myocardial infarction: Results of the thrombolysis in myocardial infarction (timi) phase ii trial, N Engl J Med, 320, pp. 618-627, (1989)

[8]

Packer M., Bristow M.R., Cohn J.N., Et al., The effect of carvedilol on morbidity and mortality in patients with chronic heart failure, N Engl J Med, 334, pp. 1349-1355, (1996)

[9]

Ryden L., Ariniego R., Arnman K., Et al., A double-blind trial of metoprolol in acute myocardial infarction. Effects on ventricular tachyarrhythmias, N Engl J Med, 308, pp. 614-618, (1983)

[10]

Mechanisms for the early mortality reduction produced by beta-blockade started early in acute myocardial infarction: Isis-1, Lancet, 1, pp. 921-923, (1988)

← 1 2 3 4 5 6 7 →