Low-dose nitric oxide therapy for persistent pulmonary hypertension: 1-Year follow-up

被引：43

作者：

Reese H Clark

Jeryl L Huckaby

Thomas J Kueser

Marshall W Walker

W Michael Southgate

Jose A Perez

Beverly J Roy

Martin Keszler

机构：

[1] Pediatrics Medical Group Inc., Sunrise, FL 3323-2825

[2] Egleston Children's Hospital, Atlanta, GA

[3] Division of Neonatology, Carolinas Medical Center, Charlotte, NC

[4] Department of Neonatology, Greenville Hospital System, Greenville, SC

[5] Medical Univesrity of South Carolina, Charleston, SC

[6] Arnold Palmer Hospital, Orlando, FL

[7] Department of Pediatrics, Emory University, Atlanta, GA

[8] Division of Neonatology, Georgetown University Hospital, Washington, DC

来源：

Journal of Perinatology | 2003年 / 23卷 / 4期

关键词：

D O I：

10.1038/sj.jp.7210908

中图分类号：

学科分类号：

摘要：

Background: Although inhaled nitric oxide has been shown to reduce the use of extracorporeal membrane oxygenation, there is limited data on its effect on long-term outcomes. Objective: The purpose of our study is to report on the 1 year outcome of neonates treated with inhaled nitric oxide compared to a group of neonates who did not receive nitric oxide. Methods: We have previously reported on the in-hospital outcomes of 248 neonates who were >34 weeks' gestational age and were randomized to receive low-dose inhaled nitric oxide or placebo. Extracorporeal membrane oxygenation was used in 78 (64%) neonates in the control group and in 48 (38%) neonates in the inhaled nitric group (p = 0.001). We now report on the outcome of neonates followed to 1 year of age. Results: Of the 248 neonates twenty-four (10%) died before 1 year of age. There was no difference in mortality between the two groups (11% in the control group and 9% in the inhaled nitric oxide group). Of the 224 surviving infants, we were able to contact the parents or guardians of 201 (90%) children. There were no intergroup differences in the numbers of patients reported as requiring medications for pulmonary disease (14% in the control group and 14% in the inhaled nitric oxide group) or the need for supplemental oxygen (1% in the control group and 0% in the inhaled nitric oxide group). The number of neonates reported to have an abnormal neurological examination or developmental delay was also similar in both groups (14% in the control group and 19% in the inhaled nitric oxide group). Conclusions: The use of low-dose inhaled nitric oxide reduces the use of extracorporeal membrane oxygenation without increasing the incidence of adverse outcomes to 1 year of age.

引用

页码：300 / 303

页数：3

共 12 条

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