Now that fecal elastase is available in the United States, should clinicians start using it?

被引：16

作者：

Lankisch P.G. ^{[1
]}

机构：

[1] Clinic of Internal Medicine, Municipal Clinic of Lueneburg, D-21339 Lueneburg

来源：

Current Gastroenterology Reports | 2004年 / 6卷 / 2期

关键词：

Chronic Pancreatitis; Celiac Disease; Exocrine Pancreatic Function; Exocrine Pancreatic Insufficiency; Pancreatic Function Test;

D O I：

10.1007/s11894-004-0039-9

中图分类号：

学科分类号：

摘要：

Fecal elastase-1 estimation is an alternative fecal enzyme test for the detection of exocrine pancreatic insufficiency, which, in contrast to chymotrypsin estimation, uses monoclonal antibodies against human pancreatic elastase and is thus unaffected by simultaneous pancreatic enzyme replacement therapy. Similar to other indirect pancreatic function test, it has a high sensitivity rate for detecting severe functional impairment of the gland. However, the two major problems for the clinician - namely diagnosing mild to moderate exocrine pancreatic insufficiency or chronic pancreatitis and differentiating pancreatic from nonpancreatic steatorrhea or diarrhea - cannot be solved by pancreatic elastase-1 determination. The test cannot be used in non-formed stool (ie, diarrhea) unless the stool is lyophilized. All in all, this new test does not seem to be the gold standard for pancreatic function that we have been waiting for. Copyright © 2004 by Current Science Inc.

引用

页码：126 / 131

页数：5

共 40 条

[1]

Lankisch P.G., Andren-Sandberg A., Standards for the diagnosis of chronic pancreatitis and for the evaluation of treatment, Int. J. Pancreatol., 14, pp. 205-212, (1993)

[2]

Layer P., Yamamoto H., Kalthoff L., Et al., The different courses of early- and late-onset idiopathic and alcoholic chronic pancreatitis, Gastroenterology, 107, pp. 1481-1487, (1994)

[3]

Lankisch P.G., Progress report: Exocrine pancreatic function tests, Gut, 23, pp. 777-798, (1982)

[4]

Lankisch P.G., Function tests in the diagnosis of chronic pancreatitis: Critical evaluation, Int. J. Pancreatol., 14, pp. 9-20, (1993)

[5]

Sziegoleit A., Krause E., Klor H.-U., Et al., Elastase 1 and chymotrypsin B in pancreatic juice and feces, Clin. Biochem., 22, pp. 85-89, (1989)

[6]

Mallory P.A., Travis J., Human pancreatic enzymes: Purification and characterization of a nonelastolytic enzyme, protease E, resembling elastase, Biochemistry, 14, pp. 722-730, (1975)

[7]

Largman C., Brodrick J.W., Geokas M.C., Purification and characterization of two human pancreatic elastases, Biochemistry, 15, pp. 2491-2500, (1976)

[8]

Sziegoleit A., A novel proteinase from human pancreas, Biochem. J., 219, pp. 735-742, (1984)

[9]

Sziegoleit A., Linder D., Studies on the sterol-binding capacity of human pancreatic elastase 1, Gastroenterology, 100, pp. 768-774, (1991)

[10]

Scheefers-Borchel U., Scheefers H., Arnold R., Et al., Pankreatische Elastase 1: Parameter für die chronische und akute Pankreatitis, Lab. Med., 16, pp. 427-432, (1992)

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