Serum uric acid as a cardiovascular risk factor for heart disease

被引：39

作者：

Alderman M.H. ^{[1
]}

机构：

[1] Albert Einstein College of Medicine, Bronx, NY 10461

来源：

Current Hypertension Reports | 2001年 / 3卷 / 3期

关键词：

Uric Acid; Xanthine Oxidase; Serum Uric Acid; Hyperuricemia; Serum Uric Acid Level;

D O I：

10.1007/s11906-001-0036-4

中图分类号：

学科分类号：

摘要：

Cardiovascular risk factors are those environmental, behavioral, genetic, and/or personal factors whose presence indicates a heightened risk of subsequent vascular disease events. Smoking, hypertension, and hyperlipidemia, initially identified by astute clinicians, were all subsequently confirmed and defined as risk factors through formal prospective epidemiologic study, long before evidence of causality was available. Ultimately, clinical trials demonstrated a reversible contribution of both high blood pressure and elevated lipids to stroke and heart disease. As a result, these risk factors are now the cornerstones for both assessment of relative cardiovascular risk and targets for preventive intervention. The criterion for risk factor status is a strong, consistent, timely, and statistically significant association to disease events that is independent of and unconfounded by other known risk factors. The purpose of this review is to assess available data to determine whether or not serum uric acid meets the standard for designation as a risk factor. Copyright © 2001 by Current Science Inc.

引用

页码：184 / 189

页数：5

共 33 条

[1]

Muscelli E., Natali A., Bianchi S., Et al., Effect of insulin on renal sodium and uric acid handling in essential hypertension, Am J Hypertens, 9, pp. 746-752, (1996)

[2]

Nakashima M., Uematsu T., Kosuge K., Kanamaru M., Pilot study of the uricosuric effect of DuP-753, a new angiotensin II receptor antagonist, in healthy subjects, Eur J Clin Pharmacol, 42, pp. 333-335, (1992)

[3]

Cannon P.J., Simson W.B., Demartini F.E., Et al., Hyperuricemia in primary and renal hypertension, N Engl J Med, 275, pp. 457-464, (1966)

[4]

Levya F., Anker S., Swan J.W., Et al., Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure, Eur Heart J, 18, pp. 858-865, (1997)

[5]

Messerli F.H., Frohlich E.D., Dreslinski G.R., Et al., Serum uric acid in essential hypertension: An indicator of renal vascular involvement, Ann Intern Med, 93, pp. 817-827, (1980)

[6]

Iossa F., Farinaro E., Panico S., Et al., Serum uric acid and hypertension: The olivetti heart study, J Hum Hypertens, 8, pp. 677-681, (1994)

[7]

Selbly I.V., Friedman G.D., Quesenberry C.P., Precursors of essential hypertension: Pulmonary function, heart rate, uric acid, serum cholesterol and other serum chemistries, Am J Epidemiol, 131, pp. 1017-1027, (1990)

[8]

Gertler M.M., Garn S.M., Levine S.A., Serum uric acid in relation to age and physique in health and in coronary heart disease, Ann Intern Med, 34, pp. 1421-1431, (1951)

[9]

Moriarity J.T., Folsom A.R., Iribarren C., Et al., Serum uric acid and risk of coronary heart disease: Atherosclerosis risk in communities (ARIC) study, Am J Epidemiol, 10, pp. 136-143, (2000)

[10]

Klein R., Klein B.E., Cornoni J.C., Et al., Serum uric acid: Its relationship to coronary heart disease risk factors and cardiovascular disease, evans county, Georgia, Arch Intern Med, 132, pp. 401-410, (1973)

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