Characteristics of c-fos gene expression in the brains of rats with different investigative and defensive behaviors

被引：8

作者：

Babai P. ^{[1
]}

Anokhin K.V. ^{[1
]}

Dolgov O.N. ^{[1
]}

Sudakov K.V. ^{[1
]}

机构：

[1] P. K. Anokhin Science Research Institute of Normal Physiology, Russian Academy of Sciences, Moscow

来源：

Neuroscience and Behavioral Physiology | 2001年 / 31卷 / 6期

基金：

俄罗斯基础研究基金会;

关键词：

Gene Expression; Cerebral Cortex; Open Field; Individual Characteristic; Brain Structure;

D O I：

10.1023/A:1012360809183

中图分类号：

学科分类号：

摘要：

Differences were found in the expression of the c-fos gene in brain structures of rats with "active" and "passive" types of behavior in the open field, hole exploration, and step-down tests. The most marked and intense expression of the c-fos gene was seen in "passive" rats. After electrocutaneous stimulation in the step-down test, these animals showed maximum expression of the c-fos gene in most areas of the cerebral cortex, the amygdala, in olfactory structures, the hypothalamus, and the brainstem. In "active" rats in the same conditions, expression of the c-fos gene was seen only in the infralimbic cortex and olfactory nuclei. These results, along with existing data on neurological mapping of the c-fos gene, demonstrate a relationship between the level and topography of c-fos expression, and with typological and, perhaps, individual characteristics of rats.

引用

页码：583 / 588

页数：5

共 7 条

[1]

Beck C.H.M., Fibiger H.C., Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: With and without diazepam pretreatment, J. Neurosci., 15, pp. 709-720, (1995)

[2]

Duncan G.E., Knapp D.J., Breese G.R., Neuroanatomical characterization of Fos induction in rat behavioral models of anxiety, Brain Res., 713, pp. 79-91, (1996)

[3]

Freeman F.M., Rose S.P., MK-801 blockade of Fos and Jun expression following passive avoidance training in the chick, Eur. J. Neurosci., 7, pp. 563-569, (1995)

[4]

Hsu S.M., Raine L., Fanger H., Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabelled antibody (PAP) procedures, J. Histochem. Cytochem., 29, pp. 577-580, (1981)

[5]

McCabe B.J., Horn G., Learning-related changes in Fos-like immunoreactivity in the chick forebrain after imprinting, Proc. Natl. Acad. Sci. USA, 91, pp. 11417-11421, (1994)

[6]

Paxinos G., Watson G., The Rat Brain in Stereotaxic Coordinates, (1986)

[7]

Swanson L.W., Brain Maps: Structure of the Rat Brain, (1992)

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