Microglial phagocytosis of dopamine neurons at early phases of apoptosis

被引：21

作者：

Byung Pil Cho ^{[1
]}

Shuei Sugama ^{[1
]}

Dong Hoon Shin ^{[1
]}

Lorraine A. DeGiorgio ^{[1
]}

Sung Soo Kim ^{[1
]}

Yoon Seong Kim ^{[1
]}

So Young Lim ^{[1
]}

Key Chung Park ^{[1
]}

Bruce T. Volpe ^{[1
]}

Sunghee Cho ^{[1
]}

Tong H. Joh ^{[1
]}

机构：

[1] Dept. of Neurology and Neuroscience, Weill Medical College, Grad. Sch. Med. Sci. Cornell Univ., White Plains, NY

[2] Dept. of Neurology and Neuroscience, Weill Medical College, Grad. Sch. Med. Sci. Cornell Univ., White Plains, NY 10605

来源：

Cellular and Molecular Neurobiology | 2003年 / 23卷 / 4-5期

关键词：

Apoptosis; Axotomy; Dopamine neurons; Microglia; Phagocytosis;

D O I：

10.1023/A:1025024129946

中图分类号：

学科分类号：

摘要：

Transection of the medial forebrain bundle caused apoptosis of dopamine neurons in the rat substantia nigra. Immunohistochemical localization of activated microglia and tyrosine hydroxylase in the axotomized substantia nigra showed that activation of microglia was rapid and OX-6 (MHC-II marker)-positive and ED1 (lysosomal phagocytic marker)-positive microglia were apposed to structurally intact tyrosine hydroxylase-positive dopamine neurons, indicating microglial phagocytosis of degenerating dopamine neurons. The occurrence of microglial phagocytosis at early stages of apoptosis may indicate the evolution of apoptosis into an irreversible state. Alternatively, interventions that suppress early activation of microglia might lead to novel mechanisms for neuron protection.

引用

页码：551 / 560

页数：9

共 33 条

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