Treatment of Dry Eye Disease with Autologous Platelet-Rich Plasma: A Prospective, Interventional, Non-Randomized Study

被引：69

作者：

Alio J.L. ^{[1
,2
]}

Rodriguez A.E. ^{[3
]}

Ferreira-Oliveira R. ^{[1
,3
]}

Wróbel-Dudzińska D. ^{[1
,3
]}

Abdelghany A.A. ^{[1
,2
,4
]}

机构：

[1] Department of Cornea and Refractive Surgery, VISSUM, Alicante

[2] Division of Ophthalmology, Universidad Miguel Hernández, Alicante

[3] Research and Development Department, VISSUM, Alicante

[4] Ophthalmology Department, Faculty of Medicine, Minia University, Minia

来源：

Ophthalmology and Therapy | 2017年 / 6卷 / 2期

关键词：

Autologous platelet-rich plasma; Autologous serum; Dry eye; Plasma rich in growth factors; PRP;

D O I：

10.1007/s40123-017-0100-z

中图分类号：

学科分类号：

摘要：

Introduction: The objective of this study was to evaluate the use of autologous platelet-rich plasma (PRP) eye drops as monotherapy for the treatment of moderate to severe cases of dry eye disease. Methods: Three hundred and sixty-eight patients with moderate to severe dry eye disease (DED) were included in this prospective case series. Subjects were classified as evaporative DED (EDED) or aqueous deficient DED (ADDED). Improvement of the DED subjective symptoms, corneal fluorescein staining (CFS), and corrected distance visual acuity (BCVA) were evaluated. We also analysed how many rounds of PRP therapy were used. Results: Two hundred and ninety-seven (80.7%) patients were women, and 71 (19.3%) were men. Two hundred and thirty-two (63%) patients had EDED, while 136 (37%) had ADDED. After 6 weeks of monotherapy treatment with autologous PRP, dry eye symptoms improved in 322 (87.5%) cases. A decrease of CFS was observed in 280 (76.1%) patients. One hundred and six (28.8%) patients improved at least 1 line of BCVA. The scores in the ocular Surface Disease Index and the Oxford scale of corneal fluorescein staining decreased statistically after the treatment (p < 0.05). Conclusion: The topical use of autologous platelet-rich plasma as monotherapy is an effective treatment to improve signs and symptoms in patients suffering from moderate to severe chronic DED. © 2017, The Author(s).

引用

页码：285 / 293

页数：8

共 29 条

[1]

The definition and classification of dry eyedisease: report of the definition and classification subcommittee of the international dry eye workshop, Ocul Surf, 5, 2, pp. 75-92, (2007)

[2]

Viso E., Rodriguez-Ares M.T., Gude F., Prevalence of and associated factors for dry eye in a Spanish adult population (the Salnes Eye Study), Ophthalmic Epidemiol., 16, 1, pp. 15-21, (2009)

[3]

Chia E.M., Mitchell P., Rochtchina E., Lee A.J., Maroun R., Wang J.J., Prevalence and associations of dry eye syndrome in an older population: the Blue Mountains Eye Study, Clin Exp Ophthalmol., 31, 3, pp. 229-232, (2003)

[4]

Gupta N., Prasad I., Jain R., D'Souza P., Estimating the prevalence of dry eye among Indian patients attending a tertiary ophthalmology clinic, Ann Trop Med Parasitol, 104, 3, pp. 247-255, (2010)

[5]

Alio J.L., Colecha J.R., Pastor S., Rodriguez A., Artola A., Symptomatic dry eye treatment with autologous platelet-rich plasma, Ophthalmic Res, 39, pp. 124-129, (2007)

[6]

Hussain M., Shtein R.M., Sugar A., Soong H.K., Woodward M.A., DeLoss K., Mian S.I., Long-term use of autologous serum 50% eye drops for the treatment of dry eye disease, Cornea, 33, 12, pp. 1245-1251, (2014)

[7]

Urzua C.A., Vasquez D.H., Huidobro A., Hernandez H., Alfaro J., Randomized double-blind clinical trial of autologous serum versus artificial tears in dry eye syndrome, Curr Eye Res, 37, 8, pp. 684-688, (2012)

[8]

Lopez-Plandolit S., Morales M.C., Freire V., Grau A.E., Duran J.A., Efficacy of plasma rich in growth factors for the treatment of dry eye, Cornea, 30, 12, pp. 1312-1317, (2011)

[9]

Alio J.L., Arnalich-Montiel F., Rodriguez A.E., The role of “Eye Platelet Rich Plasma” (E-PRP) for wound healing in ophthalmology, Curr Pharm Biotechnol., 13, 7, pp. 1257-1265, (2012)

[10]

Tandon A., Tovey J.C., Sharma A., Gupta R., Mohan R.R., Role of transforming growth factor Beta in corneal function, biology and pathology, Curr Mol Med, 10, 6, pp. 565-578, (2010)

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