The link between vitamin D deficiency and systemic lupus erythematosus

被引：54

作者：

Kamen D.L. ^{[1
]}

Aranow C. ^{[1
]}

机构：

[1] Division of Rheumatology, Medical University of South Carolina, Charleston, SC 29425

来源：

Current Rheumatology Reports | 2008年 / 10卷 / 4期

关键词：

Systemic Lupus Erythematosus; Lupus Patient; BsmI Polymorphism; Immune Health; Lupus Case;

D O I：

10.1007/s11926-008-0044-3

中图分类号：

学科分类号：

摘要：

Vitamin D deficiency is highly prevalent and is increasingly thought to be an important risk factor in many diseases that have high morbidity and mortality, including lupus. Vitamin D is an immunomodulatory hormone with effects on T cells, B cells, and dendritic cells. Animal models of autoimmune disease and epidemiologic studies suggest a role for vitamin D as a modifiable environmental factor in autoimmune disease. Recommendations are available regarding screening for and repletion of vitamin D deficiency. More research is needed to understand the role of vitamin D as an immunomodulator and to determine the optimal range of serum 25-hydroxyvitamin D for musculoskeletal, cardiovascular, and immune health. © Springer Science+Business Media, LLC 2008.

引用

页码：273 / 280

页数：7

共 68 条

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