Secretory carcinoma of the breast containing the ETV6-NTRK3 fusion gene in a male: Case report and review of the literature

被引：40

作者：

Arce C. ^{[2
]}

Cortes-Padilla D. ^{[1
]}

Huntsman D.G. ^{[5
]}

Miller M.A. ^{[6
]}

Dueñnas-Gonzalez A. ^{[4
]}

Alvarado A. ^{[1
]}

Pérez V. ^{[3
]}

Gallardo-Rincón D. ^{[1
]}

Lara-Medina F. ^{[1
]}

机构：

[1] Division of Internal Medicine, Instituto Nacional de Cancerología, Mexico

[2] Division of Clinical Research, Instituto Nacional de Cancerología, Mexico

[3] Division of Pathology, Instituto Nacional de Cancerología, Mexico

[4] Unidad de Investigacion Biomédica en Cancer, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico e Instituto Nacional de Cancerología, Mexico

[5] Genetic Pathology Evaluation Center, Department of Pathology, British Columbia Cancer Agency, Vancouver, BC

[6] General Hospital, University of British Columbia, Prostate Centre at the Vancouver General Hospital, Vancouver, BC

来源：

World Journal of Surgical Oncology | / 3卷 / 1期

关键词：

Modify Radical Mastectomy; Secretory Material; Chest Wall Recurrence; Secretory Carcinoma; Mesoblastic Nephroma;

D O I：

10.1186/1477-7819-3-35

中图分类号：

学科分类号：

摘要：

Background: Secretory carcinoma (SC) of the breast is a rare and indolent tumor. Although originally described in children, it is now known to occur in adults of both sexes. Recently, the tumor was associated with the ETV6-NTRK3 gene translocation. Case presentation: A 52-year-old male was diagnosed with secretory breast carcinoma and underwent a modified radical mastectomy. At 18 months the tumor recurred at the chest wall and the patient developed lung metastases. He was treated concurrently with radiation and chemotherapy without response. His tumor showed the ETV6-NTRK3 translocation as demonstrated by fluorescent in situ hybridization (FISH). Conclusion: SC is a rare slow-growing tumor best treated surgically. There are insufficient data to support the use of adjuvant radiation or chemotherapy. Its association with the ETV6-NTRK3 fusion gene gives some clues for the better understanding of this neoplasm and eventually, the development of specific therapies. © 2005 Arce et al; licensee BioMed Central Ltd.

引用

页数：7

共 40 条

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