Chitosan hydrogel as a drug delivery carrier to control angiogenesis

被引：120

作者：

Ishihara M. ^{[1
]}

Obara K. ^{[2
]}

Nakamura S. ^{[2
]}

Fujita M. ^{[2
,3
]}

Masuoka K. ^{[4
]}

Kanatani Y. ^{[1
]}

Takase B. ^{[1
]}

Hattori H. ^{[1
]}

Morimoto Y. ^{[3
]}

Ishihara M. ^{[1
]}

Maehara T. ^{[2
]}

Kikuchi M. ^{[1
,3
]}

机构：

[1] Research Institute, National Defense Medical College, Tokorozawa 359-8513

[2] Second Department of Surgery, National Defense Medical College, Tokorozawa

[3] Department of Medical Engineering, National Defense Medical College, Tokorozawa

[4] Department of Orthopaedic Surgery, National Defense Medical College, Tokorozawa

来源：

Journal of Artificial Organs | 2006年 / 9卷 / 1期

关键词：

Angiogenesis; Controlled release; Drug delivery carrier; Photocrosslinkable chitosan hydrogel;

D O I：

10.1007/s10047-005-0313-0

中图分类号：

学科分类号：

摘要：

An aqueous solution of photocrosslinkable chitosan containing azide groups and lactose moieties (Az-CH-LA) incorporating paclitaxel formed an insoluble hydrogel within 30s of ultraviolet light (UV) irradiation. The chitosan hydrogel showed strong potential for use as a new tissue adhesive in surgical applications and wound dressing. The fibroblast growth factor (FGF)-2 molecules retained in the chitosan hydrogel and in an injectable chitosan/IO4-heparin hydrogel remain biologically active, and were gradually released from the hydrogels as they biodegraded in vivo. The controlled release of biologically active FGF-2 molecules from the hydrogels caused induction of angiogenesis and collateral circulation occurred in healing-impaired diabetic (db/db) mice and in the ischemic limbs of rats. Paclitaxel, which is an antitumor reagent, was also retained in the chitosan hydrogel and remained biologically active as it was released on degradation of the hydrogel in vivo. The chitosan hydrogels incorporating paclitaxel effectively inhibited tumor growth and angiogenesis in mice. The purpose of this review is to describe the effectiveness of chitosan hydrogel as a local drug delivery carrier for agents (e.g., FGF-2 and paclitaxel) to control angiogenesis. It is thus proposed that chitosan hydrogel may be a promising new local carrier for drugs such as FGF-2 and paclitaxel to control vascularization. © The Japanese Society for Artificial Organs 2006.

引用

页码：8 / 16

页数：8

共 38 条

[1]

Epstein S.E., Fuchs S., Zhou Y.F., Baffour R., Kornowski R., Therapeutic interventions for enhancing collateral development by administration of growth factor: Basic principles, early results and potential hazards, Cardiovasc Res, 49, pp. 532-542, (2001)

[2]

Baffour R., Garb J.L., Kaufman J., Berman J., Rhee S.W., Norris M.A., Friedmann P., Angiogenic therapy for the chronically ischemic lower limb in a rabbit model, J Surg Res, 93, pp. 219-229, (2000)

[3]

Tabata Y., Ikada Y., Vascularization effect of basic fibroblast growth factor released from gelatin hydrogels with different biodegradabilities, Biomaterials, 20, pp. 2169-2175, (1999)

[4]

Jain R.K., Delivery of molecular medicine to solid tumors, Science, 271, pp. 1079-1080, (1996)

[5]

Au J.J.S., Jang S.H., Zheng, Chen C.T., Song S., Hu L., Wientjes M.G., Determinants of drug delivery and transport to solid tumors, J Control Rel, 74, pp. 31-46, (2001)

[6]

Nativ O., Aronson M., Medalia O., Moldavsky T., Sabo E., Ringel I., Kravtsov V., Anti-neoplastic activity of paclitaxel on experimental superficial bladder cancer: In vitro and in vivo studies, Int J Cancer, 70, pp. 297-301, (1997)

[7]

Dhanikula A.B., Panchagnula R., Localized paclitaxel delivery, Int J Pharm, 183, pp. 85-100, (1999)

[8]

Nsereko S., Amili M., Localized delivery of paclitaxel in solid tumors from biodegradable chitin microparticle formulations, Biomaterials, 23, pp. 2723-2731, (2002)

[9]

Ono K., Saito Y., Yura H., Ishikawa K., Kurita A., Ishihara M., Photocrosslinkable chitosan as a biological adhesive, J Biomed Mater Res, 49, pp. 289-295, (2000)

[10]

Ono K., Ishihara M., Ozeki Y., Deguchi H., Sato M., Saito Y., Yura H., Sato M., Kikuchi M., Kurita A., Maehara T., Experimental evaluation of photocrosslinkable chitosan as a biological adhesive with surgical application, Surgery, 130, pp. 844-850, (2001)

← 1 2 3 4 →