Metabolic syndrome: From epidemiology to systems biology

被引：234

作者：

Lusis A.J. ^{[1
,2
]}

Attie A.D. ^{[3
]}

Reue K. ^{[2
]}

机构：

[1] Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles

[2] Department of Human Genetics, University of California, Los Angeles

[3] Department of Biochemistry, University of Wisconsin-Madison, Madison

来源：

Nature Reviews Genetics | 2008年 / 9卷 / 11期

基金：

英国科研创新办公室;

关键词：

D O I：

10.1038/nrg2468

中图分类号：

学科分类号：

摘要：

Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote the development of cardiovascular disease (CVD) and diabetes. Recent genome-wide association studies have identified several novel susceptibility genes for MetSyn traits, and studies in rodent models have provided important molecular insights. However, as yet, only a small fraction of the genetic component is known. Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn. © 2008 Macmillan Publishers Limited. All rights reserved.

引用

页码：819 / 830

页数：11

共 127 条

[1]

Eckel R.H., Grundy S.M., Zimmet P.Z., The metabolic syndrome, Lancet, 365, pp. 1415-1428, (2005)

[2]

Kahn S.E., Hull R.L., Utzschneider K.M., Mechanisms linking obesity to insulin resistance and type 2 diabetes, Nature, 444, pp. 840-846, (2006)

[3]

King R.A., Rotter J.I., Motulsky A.G., The Genetic Basis of Common Disease, (2002)

[4]

Lazar M.A., How obesity causes diabetes: Not a tall tale, Science, 307, pp. 373-375, (2005)

[5]

Muoio D.M., Newgard C.B., Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes, Nature Rev. Mol. Cell Biol, 9, pp. 193-205, (2008)

[6]

Van Gaal L.F., Mertens I.L., De Block C.E., Mechanisms linking obesity with cardiovascular disease, Nature, 444, pp. 875-880, (2006)

[7]

Visscher P.M., Hill W.G., Wray N.R., Heritability in the genomics era - concepts and misconceptions, Nature Rev. Genet, 9, pp. 255-266, (2008)

[8]

Doria A., Patti M.E., Kahn C.R., The emerging genetic architecture of type 2 diabetes, Cell. Metab, 8, pp. 186-200, (2008)

[9]

Kathiresan S., Musunuru K., Orho-Melander M., Defining the spectrum of alleles that contribute to blood lipid concentrations in humans, Curr. Opin. Lipidol, 19, pp. 122-127, (2008)

[10]

Perry J.R., Frayling T.M., New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function, Curr. Opin. Clin. Nutr. Metab. Care, 11, pp. 371-377, (2008)

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