Early Diabnosis and Treatment of Neonatal Sepsis

被引:22
作者
Gerdes J.S. [1 ,2 ,3 ]
Polin R. [1 ]
机构
[1] Division of Neonatology, Department of Pediatrics, Univ. of Pennsylvania Sch. of Med., Philadelphia, PA
[2] Section on Newborn Pediatrics, Pennyslvania Hospital, Philadelphia, PA
[3] Divison of Neonatology, Dept. Pediat. Children's Hosp. P., Univ. of Pennsylvania Sch. of Med., Philadelphia, PA
关键词
Bacterial sepsis; Blood cultures; Low sensitivity;
D O I
10.1007/BF02849696
中图分类号
学科分类号
摘要
Perinatally acquired bacterial neonatal sepsis is a low incidence, high risk disease with a relatively benign treatment. Accurate diagnosis is difficult because there is no definitive diagnostic test; even blood cultures have an unacceptably low sensitivity. Therefore, the clinician must accept that a number of neonates who do not have the disease will have treatment initiated for sepsis. In order to treat rapidly all infants with sepsis and to minimize therapy for those without infection, historical, clinical, and laboratory data can be used together in a management approach to achieve optimal results. A systemized approach using history, examination, sepsis screen laboratory tests, and cultures is presented to guide clinical management.
引用
收藏
页码:63 / 78
页数:15
相关论文
共 88 条
[1]  
Freedman R.M., Ingram D.L., Gross I., Et al., A half century of neonatal sepsis at Yale, Am J Dis Child, 135, pp. 140-145, (1981)
[2]  
Hodgman J.E., Sepsis in the neonate, Perinatal/Neonatal, 5, pp. 45-50, (1981)
[3]  
Placzek M.M., Whitelaw A., Early and late neonatal septicemia, Arch Dis Child, 58, pp. 728-732, (1983)
[4]  
Philipp A.G.S., Hewitt J.R., Early diagnosis of neonatal sepsis, Pediatrics, 65, pp. 1036-1040, (1980)
[5]  
Pyati S.P., Pildes R.S., Ramamurphy R.S., Et al., Decreasing mortality in neonates with early-onset group B streptococcal infection : Reality of artifact, J Pediatr Inf Dis J, 6, pp. 177-183, (1987)
[6]  
Gerdes J.S., Polin R.A., Sepsis screen in neonates with evaluation of plasma fibronection, Pediatr Infect Dis J, 6, pp. 443-447, (1987)
[7]  
Hammerschlag M.F., Klein J.O., Herschel M., Et al., Patterns of use of antibiotics in two newborn nurseries, N Engl J Med, 295, pp. 1268-1273, (1977)
[8]  
Bennet R., Eriksson M., Nord E.C., Et al., Patterns of use of antibiotics in two newborn infants during intensive care management and treatment with five antibiotic regimens, Pediatr Infect Dis J, 5, pp. 533-538, (1986)
[9]  
Bennet R., Eriksson M., Nord C.E., Et al., Sup-pression of anerobic and anaerobic faecal flora in newborns receiving gentamicin and parenteral ampicillin, Acta Paediatr Scand, 71, pp. 559-562, (1982)
[10]  
Folli H.L., Poole R.L., Bentiz W.E., Et al., Medication error prevention by clinical pharmacists in two pediatric hospitals, Pediatrics, 79, pp. 718-723, (1987)