Angiogenesis in psoriasis and psoriatic arthritis: clues to disease pathogenesis.

被引：50

作者：

Leong T.T. ^{[1
]}

Fearon U. ^{[1
]}

Veale D.J. ^{[1
]}

机构：

[1] Department of Rheumatology, St. Vincent's University Hospital and The Conway Institute of Biomolecular and Biomedical Research, University College Dublin

来源：

Current Rheumatology Reports | 2005年 / 7卷 / 4期

关键词：

Vascular Endothelial Growth Factor; Psoriasis; Infliximab; Pioglitazone; Psoriatic Arthritis;

D O I：

10.1007/s11926-005-0044-5

中图分类号：

学科分类号：

摘要：

Psoriasis is a common chronic dermatosis occurring in 2% of the population and associated with an inflammatory arthritis--psoriatic arthritis (PsA)--in up to 40% of cases. PsA accounts for approximately 15% of patients attending early synovitis clinics, therefore it represents the second most common diagnostic category after rheumatoid arthritis. There are a number of common pathogenic features that link the skin and the joint inflammatory processes. Angiogenesis appears to be a fundamental inflammatory response early in the pathogenesis and significant abnormalities of vascular morphology and angiogenic growth factors have been described in psoriasis and PsA. This paper will explore the recent published evidence to support the hypothesis that dysregulated angiogenesis provides a primary pathogenic mechanism in psoriasis skin and in the PsA joint.

引用

页码：325 / 329

页数：4

共 30 条

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